Activities of daily living - Outcome during two years in galantamine treated Alzheimer patients

Carina Wattmo; Åsa Wallin; Lennart Minthon

Activities of daily living - Outcome during two years in galantamine treated Alzheimer patients

Carina Wattmo, Åsa Wallin, Lennart Minthon

Clinical Memory Research

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding

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Abstract

122 patients with Alzheimer's disease receiving galantamine in the Swedish Alzheimer Treatment Study were studied with respect to longitudinal change in cognition (MMSE and ADAS-cog) and function (IADL, PSMS and FAST). Particularly the FAST mean change from baseline showed a linear relationship with cognitive mean change and the strength of the relationship increased over time. The IADL scale demonstrated a faster decline of function, but significantly less than expected by using the mathematical model by Green et al. A cluster analysis was performed to reveal any natural groupings of the patients based on the functional scores at baseline. The two-cluster solution was significant; patients in cluster 1 were more cognitively impaired at baseline, they were less apt to carry the APOE e4 allele and declined faster in the outcome of PSMS score compared to the other group.

Original language	English
Title of host publication	New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2007
Publisher	Medimond
Pages	251-255
ISBN (Print)	978-88-7587-405-6
Publication status	Published - 2007
Event	8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007) - Salzburg, Austria Duration: 2007 Mar 14 → 2007 Mar 18

Conference

Conference	8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007)
Country/Territory	Austria
City	Salzburg
Period	2007/03/14 → 2007/03/18

Bibliographical note

Poster presentation

Subject classification (UKÄ)

Neurology

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Poster_Wattmo_et_al__ADPD_Salzburg_2007Final published version, 1.58 MB

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@inproceedings{636285befed349ac96d139453f8d3a6f,

title = "Activities of daily living - Outcome during two years in galantamine treated Alzheimer patients",

abstract = "122 patients with Alzheimer's disease receiving galantamine in the Swedish Alzheimer Treatment Study were studied with respect to longitudinal change in cognition (MMSE and ADAS-cog) and function (IADL, PSMS and FAST). Particularly the FAST mean change from baseline showed a linear relationship with cognitive mean change and the strength of the relationship increased over time. The IADL scale demonstrated a faster decline of function, but significantly less than expected by using the mathematical model by Green et al. A cluster analysis was performed to reveal any natural groupings of the patients based on the functional scores at baseline. The two-cluster solution was significant; patients in cluster 1 were more cognitively impaired at baseline, they were less apt to carry the APOE e4 allele and declined faster in the outcome of PSMS score compared to the other group.",

author = "Carina Wattmo and {\AA}sa Wallin and Lennart Minthon",

note = "Poster presentation; 8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007) ; Conference date: 14-03-2007 Through 18-03-2007",

year = "2007",

language = "English",

isbn = "978-88-7587-405-6",

pages = "251--255",

booktitle = "New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2007",

publisher = "Medimond",

}

TY - GEN

T1 - Activities of daily living - Outcome during two years in galantamine treated Alzheimer patients

AU - Wattmo, Carina

AU - Wallin, Åsa

AU - Minthon, Lennart

N1 - Poster presentation

PY - 2007

Y1 - 2007

N2 - 122 patients with Alzheimer's disease receiving galantamine in the Swedish Alzheimer Treatment Study were studied with respect to longitudinal change in cognition (MMSE and ADAS-cog) and function (IADL, PSMS and FAST). Particularly the FAST mean change from baseline showed a linear relationship with cognitive mean change and the strength of the relationship increased over time. The IADL scale demonstrated a faster decline of function, but significantly less than expected by using the mathematical model by Green et al. A cluster analysis was performed to reveal any natural groupings of the patients based on the functional scores at baseline. The two-cluster solution was significant; patients in cluster 1 were more cognitively impaired at baseline, they were less apt to carry the APOE e4 allele and declined faster in the outcome of PSMS score compared to the other group.

AB - 122 patients with Alzheimer's disease receiving galantamine in the Swedish Alzheimer Treatment Study were studied with respect to longitudinal change in cognition (MMSE and ADAS-cog) and function (IADL, PSMS and FAST). Particularly the FAST mean change from baseline showed a linear relationship with cognitive mean change and the strength of the relationship increased over time. The IADL scale demonstrated a faster decline of function, but significantly less than expected by using the mathematical model by Green et al. A cluster analysis was performed to reveal any natural groupings of the patients based on the functional scores at baseline. The two-cluster solution was significant; patients in cluster 1 were more cognitively impaired at baseline, they were less apt to carry the APOE e4 allele and declined faster in the outcome of PSMS score compared to the other group.

M3 - Paper in conference proceeding

SN - 978-88-7587-405-6

SP - 251

EP - 255

BT - New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2007

PB - Medimond

T2 - 8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007)

Y2 - 14 March 2007 through 18 March 2007

ER -

Activities of daily living - Outcome during two years in galantamine treated Alzheimer patients

Abstract

Conference

Bibliographical note

Subject classification (UKÄ)

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