Acute synovitis induced by preformed immune complexes

P Thomsen, Lars Magnus Bjursten, H A Hansson, U Bagge

Research output: Contribution to journalArticlepeer-review


The morphology of acute immune complex (IC) elicited synovitis in rabbit knee joints was studied, as well as IC-induced leukocyte activation in vivo and in vitro. Acute synovitis was induced by intra-articular injection of in vitro preformed, complement activating bovine serum albumin (BSA)-anti-BSA IC. Within 30 min, migration of polymorphonuclear granulocytes (PMNGs) was observed. Scanning electron microscopy showed that adhering, apparently activated leukocytes were attached to the synovial lining, often forming clusters. Phagocytosis of IC was evident, as immunoglobulins were detected within the leukocyte cytoplasm by the direct immunofluorescence technique. At the peak accumulation of PMNGs, focal erosions of the synovial lining were observed. Later, monocytes and macrophages appeared and degenerated PMNGs were found, sometimes within the cytoplasm of large macrophages. Chemiluminescence experiments showed a maximum in vitro activation of leukocytes by complement activating IC formed near optimal precipitation proportions and in slight antigen excess, whereas IC in large antigen excess gave a smaller and later response.
Original languageEnglish
Pages (from-to)134-142
JournalScandinavian Journal of Rheumatology
Issue number2
Publication statusPublished - 1986

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Bioimplant Research (013242910)

Subject classification (UKÄ)

  • Rheumatology and Autoimmunity


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