Adaptation of signal transduction in brain

Christer Alling, L Gustavsson, Christer Larsson, C Lundqvist, D Rodriguez, Per Simonsson

Research output: Contribution to journalArticlepeer-review


Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exposure which differed from the acute effects. Phosphatidylethanol formed by phospholipase D is an abnormal lipid that may harmfully affect nerve cell function.
Original languageEnglish
Pages (from-to)19-28
Publication statusPublished - 1994

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Division of Clinical Chemistry and Pharmacology (013250300), Tumour Cell Biology (013017530), Clinical Chemistry, Malmö (013016000)

Subject classification (UKÄ)

  • Medicinal Chemistry

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