Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjogren's syndrome

G. Nordmark, G. Kristjansdottir, Elke Theander, P. Eriksson, J. G. Brun, C. Wang, L. Padyukov, Lennart Truedsson, G. Alm, M-L Eloranta, R. Jonsson, L. Ronnblom, A-C Syvanen

Research output: Contribution to journalArticlepeer-review

119 Citations (SciVal)

Abstract

Primary Sjogren's syndrome (SS) shares many features with systemic lupus erythematosus (SLE). Here we investigated the association of the three major polymorphisms in IRF5 and STAT4 found to be associated with SLE, in patients from Sweden and Norway with primary SS. These polymorphisms are a 5-bp CGGGG indel in the promoter of IRF5, the single nucleotide polymorphism (SNP) rs10488631 downstream of IRF5 and the STAT4 SNP rs7582694, which tags the major risk haplotype of STAT4. We observed strong signals for association between all three polymorphisms and primary SS, with odds ratios (ORs) > 1.4 and P-values < 0.01. We also found a strong additive effect of the three risk alleles of IRF5 and STAT4 with an overall significance between the number of risk alleles and primary SS of P = 2.5 x 10(-9). The OR for primary SS increased in an additive manner, with an average increase in OR of 1.78. For carriers of two risk alleles, the OR for primary SS is 1.43, whereas carriers of five risk alleles have an OR of 6.78. IRF5 and STAT4 are components of the type I IFN system, and our findings emphasize the importance of this system in the etiopathogenesis of primary SS.
Original languageEnglish
Pages (from-to)68-76
JournalGenes and Immunity
Volume10
Issue number1
DOIs
Publication statusPublished - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Division of Microbiology, Immunology and Glycobiology - MIG (013025200)

Subject classification (UKÄ)

  • Immunology in the medical area

Keywords

  • insertion-deletion polymorphism
  • IRF5
  • primary Sjogren's syndrome
  • single nucleotide
  • STAT4
  • polymorphisms

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