Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance and response to growth hormone treatment.

Ajay Thankamony; Rikke Beck Jensen; Susan M O'Connell; Felix Day; Jeremy Kirk; Malcolm Donaldson; Sten Ivarsson; Olle Söder; Edna Roche; Hilary Hoey; Ken K Ong; David B Dunger; Anders Juul

doi:10.1210/jc.2015-3019

Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance and response to growth hormone treatment.

Ajay Thankamony, Rikke Beck Jensen, Susan M O'Connell, Felix Day, Jeremy Kirk, Malcolm Donaldson, Sten Ivarsson, Olle Söder, Edna Roche, Hilary Hoey, Ken K Ong, David B Dunger, Anders Juul

Paediatric Endocrinology

Research output: Contribution to journal › Article › peer-review

Abstract

Genetic susceptibility to insulin resistance is associated with lower adiposity in adults. Insulin resistance, and therefore adiposity, may alter sensitivity to Growth Hormone (GH). We aimed to determine the relationship between adiposity, genetic susceptibility to insulin resistance or insulin secretion, and response to GH treatment in short children born small for gestational age (SGA).

Original language	English
Pages (from-to)	jc20153019
Journal	The Journal of clinical endocrinology and metabolism
Issue number	nov 20
DOIs	https://doi.org/10.1210/jc.2015-3019
Publication status	Published - 2015

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jc.2015-3019

http://www.ncbi.nlm.nih.gov/pubmed/26588449?dopt=Abstract

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Thankamony, A., Jensen, R. B., O'Connell, S. M., Day, F., Kirk, J., Donaldson, M., Ivarsson, S., Söder, O., Roche, E., Hoey, H., Ong, K. K., Dunger, D. B., & Juul, A. (2015). Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance and response to growth hormone treatment. The Journal of clinical endocrinology and metabolism, (nov 20), jc20153019. https://doi.org/10.1210/jc.2015-3019

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title = "Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance and response to growth hormone treatment.",

abstract = "Genetic susceptibility to insulin resistance is associated with lower adiposity in adults. Insulin resistance, and therefore adiposity, may alter sensitivity to Growth Hormone (GH). We aimed to determine the relationship between adiposity, genetic susceptibility to insulin resistance or insulin secretion, and response to GH treatment in short children born small for gestational age (SGA).",

author = "Ajay Thankamony and Jensen, \{Rikke Beck\} and O'Connell, \{Susan M\} and Felix Day and Jeremy Kirk and Malcolm Donaldson and Sten Ivarsson and Olle S{\"o}der and Edna Roche and Hilary Hoey and Ong, \{Ken K\} and Dunger, \{David B\} and Anders Juul",

year = "2015",

doi = "10.1210/jc.2015-3019",

language = "English",

pages = "jc20153019",

journal = "The Journal of clinical endocrinology and metabolism",

issn = "1945-7197",

publisher = "Oxford University Press",

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Thankamony, A, Jensen, RB, O'Connell, SM, Day, F, Kirk, J, Donaldson, M, Ivarsson, S, Söder, O, Roche, E, Hoey, H, Ong, KK, Dunger, DB & Juul, A 2015, 'Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance and response to growth hormone treatment.', The Journal of clinical endocrinology and metabolism, no. nov 20, pp. jc20153019. https://doi.org/10.1210/jc.2015-3019

Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance and response to growth hormone treatment. / Thankamony, Ajay; Jensen, Rikke Beck; O'Connell, Susan M et al.
In: The Journal of clinical endocrinology and metabolism, No. nov 20, 2015, p. jc20153019.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance and response to growth hormone treatment.

AU - Thankamony, Ajay

AU - Jensen, Rikke Beck

AU - O'Connell, Susan M

AU - Day, Felix

AU - Kirk, Jeremy

AU - Donaldson, Malcolm

AU - Ivarsson, Sten

AU - Söder, Olle

AU - Roche, Edna

AU - Hoey, Hilary

AU - Ong, Ken K

AU - Dunger, David B

AU - Juul, Anders

PY - 2015

Y1 - 2015

N2 - Genetic susceptibility to insulin resistance is associated with lower adiposity in adults. Insulin resistance, and therefore adiposity, may alter sensitivity to Growth Hormone (GH). We aimed to determine the relationship between adiposity, genetic susceptibility to insulin resistance or insulin secretion, and response to GH treatment in short children born small for gestational age (SGA).

AB - Genetic susceptibility to insulin resistance is associated with lower adiposity in adults. Insulin resistance, and therefore adiposity, may alter sensitivity to Growth Hormone (GH). We aimed to determine the relationship between adiposity, genetic susceptibility to insulin resistance or insulin secretion, and response to GH treatment in short children born small for gestational age (SGA).

UR - https://www.scopus.com/pages/publications/84954480886

U2 - 10.1210/jc.2015-3019

DO - 10.1210/jc.2015-3019

M3 - Article

C2 - 26588449

SN - 1945-7197

SP - jc20153019

JO - The Journal of clinical endocrinology and metabolism

JF - The Journal of clinical endocrinology and metabolism

IS - nov 20

ER -

Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance and response to growth hormone treatment.

Abstract

Subject classification (UKÄ)

UN SDGs

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