Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach

Maria Ruchkina; Akvile Zabiliute-Karaliune; Egle Bukarte; Adam Kinos; David Hill; Alexander Bengtsson; Kevin Shortiss; Nina Reistad; Lars Rippe; Johannes Swartling; Sophia Zackrisson; Predrag Bakic; Laszlo Kovacs; Zsolt Kis; Zsuzsanna Szaller; Krisztian Lengyel; Charles Thiel; Stefan Kröll

doi:10.1117/12.3023883

Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach

Maria Ruchkina, Akvile Zabiliute-Karaliune, Egle Bukarte, Adam Kinos, David Hill, Alexander Bengtsson, Kevin Shortiss, Nina Reistad, Lars Rippe, Johannes Swartling, Sophia Zackrisson, Predrag Bakic, Laszlo Kovacs, Zsolt Kis, Zsuzsanna Szaller, Krisztian Lengyel, Charles Thiel, Stefan Kröll

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

Abstract

Each year, about 30% of all newly diagnosed cancer cases in women worldwide are breast cancers [1]. One of the most common techniques for breast cancer diagnosis is mammography. However, this technique provides limited functional information regarding breast tissue morphology. In cases of suspected malignancy invasive techniques such as biopsy are implemented.
In this work an optical deep tissue imaging technique called ultrasound optical tomography (UOT) which combines laser light and ultrasound is implemented for a non-invasive lesion (tumour) characterization in breast tissue.
The experiments were performed using 794 nm laser wavelength, 6 MHz ultrasound frequency and a narrowband spectral filter material, Tm3+:LiNbO3. The measurements were carried out in 5 cm thick agar phantoms using a range of tumor mimicking inclusions of 3 different sizes.
This work is the first deep tissue imaging demonstration using UOT at tissue relevant wavelengths. Current results indicate that the UOT technique can become an important and valuable tool for lesion characterization in breast tissue.

Original language	English
Title of host publication	Tissue Optics and Photonics III
Subtitle of host publication	PROCEEDINGS VOLUME 13010 SPIE PHOTONICS EUROPE \| 7-12 APRIL 2024
Editors	Valery V. Tuchin, Walter C.P.M. Blondel, Zeev Zalevsky
Publisher	SPIE
Pages	1301006
Number of pages	6
Volume	13010
DOIs	https://doi.org/10.1117/12.3023883
Publication status	Published - 2024
Event	SPIE Photonics Europe, 2024, Strasbourg, France: Tissue Optics and Photonics III - Strasbourg, France Duration: 2024 Jun 18 → …

Conference

Conference	SPIE Photonics Europe, 2024, Strasbourg, France
Country/Territory	France
City	Strasbourg
Period	2024/06/18 → …

Subject classification (UKÄ)

Radiology, Nuclear Medicine and Medical Imaging
Atom and Molecular Physics and Optics

Free keywords

breast cancer
bio-medical imaging
diagnosis
ultrasound optical tomography
deep tissue imaging
acousto-optic effect
spectral-hole-burning filters
rare-earth-ion-doped crystals

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.3023883

Cite this

Ruchkina, M., Zabiliute-Karaliune, A., Bukarte, E., Kinos, A., Hill, D., Bengtsson, A., Shortiss, K., Reistad, N., Rippe, L., Swartling, J., Zackrisson, S., Bakic, P., Kovacs, L., Kis, Z., Szaller, Z., Lengyel, K., Thiel, C., & Kröll, S. (2024). Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach. In V. V. Tuchin, W. C. P. M. Blondel, & Z. Zalevsky (Eds.), Tissue Optics and Photonics III: PROCEEDINGS VOLUME 13010 SPIE PHOTONICS EUROPE | 7-12 APRIL 2024 (Vol. 13010, pp. 1301006). SPIE. https://doi.org/10.1117/12.3023883

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title = "Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach",

abstract = "Each year, about 30% of all newly diagnosed cancer cases in women worldwide are breast cancers [1]. One of the most common techniques for breast cancer diagnosis is mammography. However, this technique provides limited functional information regarding breast tissue morphology. In cases of suspected malignancy invasive techniques such as biopsy are implemented.In this work an optical deep tissue imaging technique called ultrasound optical tomography (UOT) which combines laser light and ultrasound is implemented for a non-invasive lesion (tumour) characterization in breast tissue.The experiments were performed using 794 nm laser wavelength, 6 MHz ultrasound frequency and a narrowband spectral filter material, Tm3+:LiNbO3. The measurements were carried out in 5 cm thick agar phantoms using a range of tumor mimicking inclusions of 3 different sizes.This work is the first deep tissue imaging demonstration using UOT at tissue relevant wavelengths. Current results indicate that the UOT technique can become an important and valuable tool for lesion characterization in breast tissue.",

keywords = "breast cancer, bio-medical imaging, diagnosis, ultrasound optical tomography, deep tissue imaging, acousto-optic effect, spectral-hole-burning filters, rare-earth-ion-doped crystals",

author = "Maria Ruchkina and Akvile Zabiliute-Karaliune and Egle Bukarte and Adam Kinos and David Hill and Alexander Bengtsson and Kevin Shortiss and Nina Reistad and Lars Rippe and Johannes Swartling and Sophia Zackrisson and Predrag Bakic and Laszlo Kovacs and Zsolt Kis and Zsuzsanna Szaller and Krisztian Lengyel and Charles Thiel and Stefan Kr{\"o}ll",

year = "2024",

doi = "10.1117/12.3023883",

language = "English",

volume = "13010",

pages = "1301006",

editor = "Tuchin, {Valery V.} and Blondel, {Walter C.P.M.} and Zeev Zalevsky",

booktitle = "Tissue Optics and Photonics III",

publisher = "SPIE",

address = "United States",

note = " SPIE Photonics Europe, 2024, Strasbourg, France : Tissue Optics and Photonics III ; Conference date: 18-06-2024",

}

Ruchkina, M , Zabiliute-Karaliune, A, Bukarte, E, Kinos, A, Hill, D, Bengtsson, A, Shortiss, K, Reistad, N , Rippe, L, Swartling, J, Zackrisson, S , Bakic, P, Kovacs, L, Kis, Z, Szaller, Z, Lengyel, K, Thiel, C & Kröll, S 2024, Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach. in VV Tuchin, WCPM Blondel & Z Zalevsky (eds), Tissue Optics and Photonics III: PROCEEDINGS VOLUME 13010 SPIE PHOTONICS EUROPE | 7-12 APRIL 2024. vol. 13010, SPIE, pp. 1301006, SPIE Photonics Europe, 2024, Strasbourg, France, Strasbourg, France, 2024/06/18. https://doi.org/10.1117/12.3023883

Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach. / Ruchkina, Maria ; Zabiliute-Karaliune, Akvile; Bukarte, Egle et al.
Tissue Optics and Photonics III: PROCEEDINGS VOLUME 13010 SPIE PHOTONICS EUROPE | 7-12 APRIL 2024. ed. / Valery V. Tuchin; Walter C.P.M. Blondel; Zeev Zalevsky. Vol. 13010 SPIE, 2024. p. 1301006.

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

TY - GEN

T1 - Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach

AU - Ruchkina, Maria

AU - Zabiliute-Karaliune, Akvile

AU - Bukarte, Egle

AU - Kinos, Adam

AU - Hill, David

AU - Bengtsson, Alexander

AU - Shortiss, Kevin

AU - Reistad, Nina

AU - Rippe, Lars

AU - Swartling, Johannes

AU - Zackrisson, Sophia

AU - Bakic, Predrag

AU - Kovacs, Laszlo

AU - Kis, Zsolt

AU - Szaller, Zsuzsanna

AU - Lengyel, Krisztian

AU - Thiel, Charles

AU - Kröll, Stefan

PY - 2024

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N2 - Each year, about 30% of all newly diagnosed cancer cases in women worldwide are breast cancers [1]. One of the most common techniques for breast cancer diagnosis is mammography. However, this technique provides limited functional information regarding breast tissue morphology. In cases of suspected malignancy invasive techniques such as biopsy are implemented.In this work an optical deep tissue imaging technique called ultrasound optical tomography (UOT) which combines laser light and ultrasound is implemented for a non-invasive lesion (tumour) characterization in breast tissue.The experiments were performed using 794 nm laser wavelength, 6 MHz ultrasound frequency and a narrowband spectral filter material, Tm3+:LiNbO3. The measurements were carried out in 5 cm thick agar phantoms using a range of tumor mimicking inclusions of 3 different sizes.This work is the first deep tissue imaging demonstration using UOT at tissue relevant wavelengths. Current results indicate that the UOT technique can become an important and valuable tool for lesion characterization in breast tissue.

AB - Each year, about 30% of all newly diagnosed cancer cases in women worldwide are breast cancers [1]. One of the most common techniques for breast cancer diagnosis is mammography. However, this technique provides limited functional information regarding breast tissue morphology. In cases of suspected malignancy invasive techniques such as biopsy are implemented.In this work an optical deep tissue imaging technique called ultrasound optical tomography (UOT) which combines laser light and ultrasound is implemented for a non-invasive lesion (tumour) characterization in breast tissue.The experiments were performed using 794 nm laser wavelength, 6 MHz ultrasound frequency and a narrowband spectral filter material, Tm3+:LiNbO3. The measurements were carried out in 5 cm thick agar phantoms using a range of tumor mimicking inclusions of 3 different sizes.This work is the first deep tissue imaging demonstration using UOT at tissue relevant wavelengths. Current results indicate that the UOT technique can become an important and valuable tool for lesion characterization in breast tissue.

KW - breast cancer

KW - bio-medical imaging

KW - diagnosis

KW - ultrasound optical tomography

KW - deep tissue imaging

KW - acousto-optic effect

KW - spectral-hole-burning filters

KW - rare-earth-ion-doped crystals

U2 - 10.1117/12.3023883

DO - 10.1117/12.3023883

M3 - Paper in conference proceeding

VL - 13010

SP - 1301006

BT - Tissue Optics and Photonics III

A2 - Tuchin, Valery V.

A2 - Blondel, Walter C.P.M.

A2 - Zalevsky, Zeev

PB - SPIE

T2 - SPIE Photonics Europe, 2024, Strasbourg, France

Y2 - 18 June 2024

ER -

Ruchkina M , Zabiliute-Karaliune A, Bukarte E, Kinos A, Hill D, Bengtsson A et al. Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach. In Tuchin VV, Blondel WCPM, Zalevsky Z, editors, Tissue Optics and Photonics III: PROCEEDINGS VOLUME 13010 SPIE PHOTONICS EUROPE | 7-12 APRIL 2024. Vol. 13010. SPIE. 2024. p. 1301006 doi: 10.1117/12.3023883

Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach

Abstract

Conference

Subject classification (UKÄ)

Free keywords

UN SDGs

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