Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study

Maiwand Farouq; Cecilia Rorsman; Sofia Marinko; David Mörtsell; Uzma Chaudhry; Lingwei Wang; Pyotr Platonov; Rasmus Borgquist

doi:10.1093/europace/euad187

Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study

Maiwand Farouq, Cecilia Rorsman, Sofia Marinko, David Mörtsell, Uzma Chaudhry, Lingwei Wang, Pyotr Platonov, Rasmus Borgquist

Research output: Contribution to journal › Article › peer-review

Abstract

Background and aims
Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).

Methods
All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.

Results
4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p
Conclusion
In this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged

Original language	English
Article number	euad187
Journal	Europace
Volume	25
Issue number	7
DOIs	https://doi.org/10.1093/europace/euad187
Publication status	Published - 2023 Jul 1

Subject classification (UKÄ)

Cardiology and Cardiovascular Disease

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10.1093/europace/euad187Licence: CC BY-NC

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Farouq, M., Rorsman, C., Marinko, S., Mörtsell, D., Chaudhry, U., Wang, L., Platonov, P., & Borgquist, R. (2023). Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study. Europace, 25(7), Article euad187. https://doi.org/10.1093/europace/euad187

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title = "Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study",

abstract = "Background and aimsPrior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).MethodsAll patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.Results4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p ConclusionIn this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged ",

author = "Maiwand Farouq and Cecilia Rorsman and Sofia Marinko and David M{\"o}rtsell and Uzma Chaudhry and Lingwei Wang and Pyotr Platonov and Rasmus Borgquist",

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doi = "10.1093/europace/euad187",

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T1 - Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study

AU - Farouq, Maiwand

AU - Rorsman, Cecilia

AU - Marinko, Sofia

AU - Mörtsell, David

AU - Chaudhry, Uzma

AU - Wang, Lingwei

AU - Platonov, Pyotr

AU - Borgquist, Rasmus

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Background and aimsPrior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).MethodsAll patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.Results4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p ConclusionIn this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged

AB - Background and aimsPrior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).MethodsAll patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.Results4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p ConclusionIn this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged

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DO - 10.1093/europace/euad187

M3 - Article

C2 - 37392462

SN - 1532-2092

VL - 25

JO - Europace

JF - Europace

IS - 7

M1 - euad187

ER -

Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study

Abstract

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