Agreement between nonculprit stenosis follow-up iFR and FFR after STEMI (iSTEMI substudy)

Troels Thim; Matthias Götberg; Ole Fröbert; Robin Nijveldt; Niels van Royen; Sergio Bravo Baptista; Sasha Koul; Thomas Kellerth; Hans Erik Bøtker; Christian Juhl Terkelsen; Evald Høj Christiansen; Lars Jakobsen; Steen Dalby Kristensen; Michael Maeng

doi:10.1186/s13104-020-05252-6

Agreement between nonculprit stenosis follow-up iFR and FFR after STEMI (iSTEMI substudy)

Troels Thim, Matthias Götberg, Ole Fröbert, Robin Nijveldt, Niels van Royen, Sergio Bravo Baptista, Sasha Koul, Thomas Kellerth, Hans Erik Bøtker, Christian Juhl Terkelsen, Evald Høj Christiansen, Lars Jakobsen, Steen Dalby Kristensen, Michael Maeng

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To evaluate agreement between instantaneous wave free ratio (iFR) and fractional flow reserve (FFR) for the functional assessment of nonculprit coronary stenoses at staged follow-up after ST-segment elevation myocardial infarction (STEMI). RESULTS: We measured iFR and FFR at staged follow-up in 112 STEMI patients with 146 nonculprit stenoses. Median interval between STEMI and follow-up was 16 (interquartile range 5-32) days. Agreement between iFR and FFR was 77% < 5 days after STEMI and 86% after ≥ 5 days (p = 0.19). Among cases with disagreement, the proportion of cases with hemodynamically significant iFR and non-significant FFR were different when assessed < 5 days (5 in 8, 63%) versus ≥ 5 days (3 in 15, 20%) after STEMI (p = 0.04). Overall classification agreement between iFR and FFR was comparable to that observed in stable patients. Time interval between STEMI and follow-up evaluation may impact agreement between iFR and FFR.

Original language	English
Article number	410
Journal	BMC Research Notes
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s13104-020-05252-6
Publication status	Published - 2020
Externally published	Yes

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems

Free keywords

FFR
Fractional flow reserve
iFR
Instantaneous wave-free ration
Nonculprit stenosis
ST-segment elevation myocardial infarction

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10.1186/s13104-020-05252-6

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Thim, T., Götberg, M., Fröbert, O., Nijveldt, R., van Royen, N., Baptista, S. B., Koul, S., Kellerth, T., Bøtker, H. E., Terkelsen, C. J., Christiansen, E. H., Jakobsen, L., Kristensen, S. D., & Maeng, M. (2020). Agreement between nonculprit stenosis follow-up iFR and FFR after STEMI (iSTEMI substudy). BMC Research Notes, 13(1), Article 410. https://doi.org/10.1186/s13104-020-05252-6

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title = "Agreement between nonculprit stenosis follow-up iFR and FFR after STEMI (iSTEMI substudy)",

abstract = "OBJECTIVE: To evaluate agreement between instantaneous wave free ratio (iFR) and fractional flow reserve (FFR) for the functional assessment of nonculprit coronary stenoses at staged follow-up after ST-segment elevation myocardial infarction (STEMI). RESULTS: We measured iFR and FFR at staged follow-up in 112 STEMI patients with 146 nonculprit stenoses. Median interval between STEMI and follow-up was 16 (interquartile range 5-32) days. Agreement between iFR and FFR was 77% < 5 days after STEMI and 86% after ≥ 5 days (p = 0.19). Among cases with disagreement, the proportion of cases with hemodynamically significant iFR and non-significant FFR were different when assessed < 5 days (5 in 8, 63%) versus ≥ 5 days (3 in 15, 20%) after STEMI (p = 0.04). Overall classification agreement between iFR and FFR was comparable to that observed in stable patients. Time interval between STEMI and follow-up evaluation may impact agreement between iFR and FFR.",

keywords = "FFR, Fractional flow reserve, iFR, Instantaneous wave-free ration, Nonculprit stenosis, ST-segment elevation myocardial infarction",

author = "Troels Thim and Matthias G{\"o}tberg and Ole Fr{\"o}bert and Robin Nijveldt and {van Royen}, Niels and Baptista, {Sergio Bravo} and Sasha Koul and Thomas Kellerth and B{\o}tker, {Hans Erik} and Terkelsen, {Christian Juhl} and Christiansen, {Evald H{\o}j} and Lars Jakobsen and Kristensen, {Steen Dalby} and Michael Maeng",

year = "2020",

doi = "10.1186/s13104-020-05252-6",

language = "English",

volume = "13",

journal = "BMC Research Notes",

issn = "1756-0500",

publisher = "BioMed Central (BMC)",

number = "1",

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TY - JOUR

T1 - Agreement between nonculprit stenosis follow-up iFR and FFR after STEMI (iSTEMI substudy)

AU - Thim, Troels

AU - Götberg, Matthias

AU - Fröbert, Ole

AU - Nijveldt, Robin

AU - van Royen, Niels

AU - Baptista, Sergio Bravo

AU - Koul, Sasha

AU - Kellerth, Thomas

AU - Bøtker, Hans Erik

AU - Terkelsen, Christian Juhl

AU - Christiansen, Evald Høj

AU - Jakobsen, Lars

AU - Kristensen, Steen Dalby

AU - Maeng, Michael

PY - 2020

Y1 - 2020

N2 - OBJECTIVE: To evaluate agreement between instantaneous wave free ratio (iFR) and fractional flow reserve (FFR) for the functional assessment of nonculprit coronary stenoses at staged follow-up after ST-segment elevation myocardial infarction (STEMI). RESULTS: We measured iFR and FFR at staged follow-up in 112 STEMI patients with 146 nonculprit stenoses. Median interval between STEMI and follow-up was 16 (interquartile range 5-32) days. Agreement between iFR and FFR was 77% < 5 days after STEMI and 86% after ≥ 5 days (p = 0.19). Among cases with disagreement, the proportion of cases with hemodynamically significant iFR and non-significant FFR were different when assessed < 5 days (5 in 8, 63%) versus ≥ 5 days (3 in 15, 20%) after STEMI (p = 0.04). Overall classification agreement between iFR and FFR was comparable to that observed in stable patients. Time interval between STEMI and follow-up evaluation may impact agreement between iFR and FFR.

AB - OBJECTIVE: To evaluate agreement between instantaneous wave free ratio (iFR) and fractional flow reserve (FFR) for the functional assessment of nonculprit coronary stenoses at staged follow-up after ST-segment elevation myocardial infarction (STEMI). RESULTS: We measured iFR and FFR at staged follow-up in 112 STEMI patients with 146 nonculprit stenoses. Median interval between STEMI and follow-up was 16 (interquartile range 5-32) days. Agreement between iFR and FFR was 77% < 5 days after STEMI and 86% after ≥ 5 days (p = 0.19). Among cases with disagreement, the proportion of cases with hemodynamically significant iFR and non-significant FFR were different when assessed < 5 days (5 in 8, 63%) versus ≥ 5 days (3 in 15, 20%) after STEMI (p = 0.04). Overall classification agreement between iFR and FFR was comparable to that observed in stable patients. Time interval between STEMI and follow-up evaluation may impact agreement between iFR and FFR.

KW - FFR

KW - Fractional flow reserve

KW - iFR

KW - Instantaneous wave-free ration

KW - Nonculprit stenosis

KW - ST-segment elevation myocardial infarction

U2 - 10.1186/s13104-020-05252-6

DO - 10.1186/s13104-020-05252-6

M3 - Article

C2 - 32873327

AN - SCOPUS:85090182231

SN - 1756-0500

VL - 13

JO - BMC Research Notes

JF - BMC Research Notes

IS - 1

M1 - 410

ER -

Agreement between nonculprit stenosis follow-up iFR and FFR after STEMI (iSTEMI substudy)

Abstract

Subject classification (UKÄ)

Free keywords

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