Airborne chemistry coupled to Raman spectroscopy

Sabina Santesson; Jonas Johansson; Lynne S Taylor; Ia Levander; Shannon Fox; Michael Sepaniak; Staffan Nilsson

doi:10.1021/ac026302w

Airborne chemistry coupled to Raman spectroscopy

Sabina Santesson, Jonas Johansson, Lynne S Taylor, Ia Levander, Shannon Fox, Michael Sepaniak, Staffan Nilsson

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

Abstract

In this paper, the use of airborne chemistry (acoustically levitated drops) in combination with Raman spectroscopy is explored. We report herein the first Raman studies of crystallization processes in levitated drops and the first demonstration of surface-enhanced Raman scattering (SERS) detection in this medium. Crystallization studies on the model compounds benzamide and indomethacin resulted in the formation of two crystal modifications for each compound, suggesting that this methodology may be useful for investigation of polymorphs. SERS detection resulted in a signal enhancement of 27 000 for benzoic acid and 11 000 for rhodamine 6-G. The preliminary results presented here clearly indicate that several important applications of the combination between Raman spectroscopy and acoustic drop levitation can be expected in the future.

Original language	English
Pages (from-to)	2177-2180
Journal	Analytical Chemistry
Volume	75
Issue number	9
DOIs	https://doi.org/10.1021/ac026302w
Publication status	Published - 2003

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)

Subject classification (UKÄ)

Analytical Chemistry

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10.1021/ac026302w

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title = "Airborne chemistry coupled to Raman spectroscopy",

abstract = "In this paper, the use of airborne chemistry (acoustically levitated drops) in combination with Raman spectroscopy is explored. We report herein the first Raman studies of crystallization processes in levitated drops and the first demonstration of surface-enhanced Raman scattering (SERS) detection in this medium. Crystallization studies on the model compounds benzamide and indomethacin resulted in the formation of two crystal modifications for each compound, suggesting that this methodology may be useful for investigation of polymorphs. SERS detection resulted in a signal enhancement of 27 000 for benzoic acid and 11 000 for rhodamine 6-G. The preliminary results presented here clearly indicate that several important applications of the combination between Raman spectroscopy and acoustic drop levitation can be expected in the future.",

author = "Sabina Santesson and Jonas Johansson and Taylor, {Lynne S} and Ia Levander and Shannon Fox and Michael Sepaniak and Staffan Nilsson",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)",

year = "2003",

doi = "10.1021/ac026302w",

language = "English",

volume = "75",

pages = "2177--2180",

journal = "Analytical Chemistry",

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T1 - Airborne chemistry coupled to Raman spectroscopy

AU - Santesson, Sabina

AU - Johansson, Jonas

AU - Taylor, Lynne S

AU - Levander, Ia

AU - Fox, Shannon

AU - Sepaniak, Michael

AU - Nilsson, Staffan

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)

PY - 2003

Y1 - 2003

N2 - In this paper, the use of airborne chemistry (acoustically levitated drops) in combination with Raman spectroscopy is explored. We report herein the first Raman studies of crystallization processes in levitated drops and the first demonstration of surface-enhanced Raman scattering (SERS) detection in this medium. Crystallization studies on the model compounds benzamide and indomethacin resulted in the formation of two crystal modifications for each compound, suggesting that this methodology may be useful for investigation of polymorphs. SERS detection resulted in a signal enhancement of 27 000 for benzoic acid and 11 000 for rhodamine 6-G. The preliminary results presented here clearly indicate that several important applications of the combination between Raman spectroscopy and acoustic drop levitation can be expected in the future.

AB - In this paper, the use of airborne chemistry (acoustically levitated drops) in combination with Raman spectroscopy is explored. We report herein the first Raman studies of crystallization processes in levitated drops and the first demonstration of surface-enhanced Raman scattering (SERS) detection in this medium. Crystallization studies on the model compounds benzamide and indomethacin resulted in the formation of two crystal modifications for each compound, suggesting that this methodology may be useful for investigation of polymorphs. SERS detection resulted in a signal enhancement of 27 000 for benzoic acid and 11 000 for rhodamine 6-G. The preliminary results presented here clearly indicate that several important applications of the combination between Raman spectroscopy and acoustic drop levitation can be expected in the future.

U2 - 10.1021/ac026302w

DO - 10.1021/ac026302w

M3 - Article

C2 - 12720359

SN - 1520-6882

VL - 75

SP - 2177

EP - 2180

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 9

ER -

Airborne chemistry coupled to Raman spectroscopy

Abstract

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