Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

H. Laura Aaltonen, Madeleine Petersson Sjögren, Jonas K.F. Jakobsson, Hanna Nicklasson, Sandra Diaz, Francisco Sánchez Montiel, Sophia Zackrisson, Veronica Ideböhn, Gunnar Engström, Jakob Löndahl, Per Wollmer

Research output: Contribution to journalArticlepeer-review


Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.

Original languageEnglish
Pages (from-to)1040-1043
Issue number10
Early online date2021
Publication statusPublished - 2021

Subject classification (UKÄ)

  • Respiratory Medicine and Allergy
  • Radiology, Nuclear Medicine and Medical Imaging

Free keywords

  • emphysema
  • exhaled airway markers
  • imaging/CT MRI
  • respiratory measurement


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