Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

H. Laura Aaltonen; Madeleine Petersson Sjögren; Jonas K.F. Jakobsson; Hanna Nicklasson; Sandra Diaz; Francisco Sánchez Montiel; Sophia Zackrisson; Veronica Ideböhn; Gunnar Engström; Jakob Löndahl; Per Wollmer

doi:10.1136/thoraxjnl-2020-214523

Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

H. Laura Aaltonen, Madeleine Petersson Sjögren, Jonas K.F. Jakobsson, Hanna Nicklasson, Sandra Diaz, Francisco Sánchez Montiel, Sophia Zackrisson, Veronica Ideböhn, Gunnar Engström, Jakob Löndahl, Per Wollmer

Research output: Contribution to journal › Article › peer-review

Abstract

Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.

Original language	English
Pages (from-to)	1040-1043
Journal	Thorax
Volume	76
Issue number	10
Early online date	2021
DOIs	https://doi.org/10.1136/thoraxjnl-2020-214523
Publication status	Published - 2021

Subject classification (UKÄ)

Respiratory Medicine and Allergy
Radiology, Nuclear Medicine and Medical Imaging

Keywords

emphysema
exhaled airway markers
imaging/CT MRI
respiratory measurement

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10.1136/thoraxjnl-2020-214523Licence: CC BY

Cite this

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title = "Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema",

abstract = "Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.",

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author = "Aaltonen, {H. Laura} and {Petersson Sj{\"o}gren}, Madeleine and Jakobsson, {Jonas K.F.} and Hanna Nicklasson and Sandra Diaz and {S{\'a}nchez Montiel}, Francisco and Sophia Zackrisson and Veronica Ideb{\"o}hn and Gunnar Engstr{\"o}m and Jakob L{\"o}ndahl and Per Wollmer",

year = "2021",

doi = "10.1136/thoraxjnl-2020-214523",

language = "English",

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T1 - Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

AU - Aaltonen, H. Laura

AU - Petersson Sjögren, Madeleine

AU - Jakobsson, Jonas K.F.

AU - Nicklasson, Hanna

AU - Diaz, Sandra

AU - Sánchez Montiel, Francisco

AU - Zackrisson, Sophia

AU - Ideböhn, Veronica

AU - Engström, Gunnar

AU - Löndahl, Jakob

AU - Wollmer, Per

PY - 2021

Y1 - 2021

N2 - Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.

AB - Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.

KW - emphysema

KW - exhaled airway markers

KW - imaging/CT MRI

KW - respiratory measurement

U2 - 10.1136/thoraxjnl-2020-214523

DO - 10.1136/thoraxjnl-2020-214523

M3 - Article

C2 - 33859054

AN - SCOPUS:85104459368

VL - 76

SP - 1040

EP - 1043

JO - Thorax

JF - Thorax

SN - 1468-3296

IS - 10

ER -

Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

Abstract

Subject classification (UKÄ)

Keywords

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