Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.

Asger Sverrild; Anders Bergqvist; Katherine J Baines; Celeste Porsbjerg; Cecilia Andersson; Simon Francis Thomsen; Hans Jürgen Hoffmann; Peter Gibson; Jonas Erjefält; Vibeke Backer

doi:10.1111/cea.12609

Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.

Asger Sverrild, Anders Bergqvist, Katherine J Baines, Celeste Porsbjerg, Cecilia Andersson, Simon Francis Thomsen, Hans Jürgen Hoffmann, Peter Gibson, Jonas Erjefält, Vibeke Backer

Airway Inflammation and Immunology

Research output: Contribution to journal › Article › peer-review

Abstract

Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway inflammation. It is unknown how AHR to mannitol relates to mast cell phenotype, mast cell function and measures of eosinophilic inflammation in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell associated genes and number of eosinophils in airway tissue of subjects with asthma and healthy controls in relation to AHR to mannitol.

Original language	English
Pages (from-to)	288-297
Journal	Clinical and Experimental Allergy
Volume	46
Issue number	2
Early online date	2015 Aug 7
DOIs	https://doi.org/10.1111/cea.12609
Publication status	Published - 2016

Subject classification (UKÄ)

Respiratory Medicine and Allergy

Access to Document

10.1111/cea.12609

http://www.ncbi.nlm.nih.gov/pubmed/26252943?dopt=Abstract

Cite this

@article{899e97fe150c4355a31f361ce9eedbd2,

title = "Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.",

abstract = "Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway inflammation. It is unknown how AHR to mannitol relates to mast cell phenotype, mast cell function and measures of eosinophilic inflammation in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell associated genes and number of eosinophils in airway tissue of subjects with asthma and healthy controls in relation to AHR to mannitol.",

author = "Asger Sverrild and Anders Bergqvist and Baines, {Katherine J} and Celeste Porsbjerg and Cecilia Andersson and Thomsen, {Simon Francis} and Hoffmann, {Hans J{\"u}rgen} and Peter Gibson and Jonas Erjef{\"a}lt and Vibeke Backer",

year = "2016",

doi = "10.1111/cea.12609",

language = "English",

volume = "46",

pages = "288--297",

journal = "Clinical and Experimental Allergy",

issn = "1365-2222",

publisher = "Wiley",

number = "2",

}

TY - JOUR

T1 - Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.

AU - Sverrild, Asger

AU - Bergqvist, Anders

AU - Baines, Katherine J

AU - Porsbjerg, Celeste

AU - Andersson, Cecilia

AU - Thomsen, Simon Francis

AU - Hoffmann, Hans Jürgen

AU - Gibson, Peter

AU - Erjefält, Jonas

AU - Backer, Vibeke

PY - 2016

Y1 - 2016

N2 - Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway inflammation. It is unknown how AHR to mannitol relates to mast cell phenotype, mast cell function and measures of eosinophilic inflammation in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell associated genes and number of eosinophils in airway tissue of subjects with asthma and healthy controls in relation to AHR to mannitol.

AB - Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway inflammation. It is unknown how AHR to mannitol relates to mast cell phenotype, mast cell function and measures of eosinophilic inflammation in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell associated genes and number of eosinophils in airway tissue of subjects with asthma and healthy controls in relation to AHR to mannitol.

U2 - 10.1111/cea.12609

DO - 10.1111/cea.12609

M3 - Article

C2 - 26252943

SN - 1365-2222

VL - 46

SP - 288

EP - 297

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

IS - 2

ER -

Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.

Abstract

Subject classification (UKÄ)

Access to Document

Fingerprint

Cite this