TY - JOUR
T1 - Alcohol consumption and common carotid intima-media thickness
T2 - The USE-IMT study
AU - Britton, Annie R
AU - Grobbee, Diederick E.
AU - Den Ruijter, Hester M.
AU - Anderson, Todd J
AU - Desvarieux, Moise
AU - Engström, Gunnar
AU - Evans, Greg W
AU - Hedblad, Bo
AU - Kauhanen, Jussi
AU - Kurl, Sudhir
AU - Lonn, Eva M
AU - Mathiesen, Ellisiv B
AU - Polak, Joseph F
AU - Price, Jacqueline F.
AU - Rembold, Christopher M
AU - Rosvall, Maria
AU - Rundek, Tatjana
AU - Salonen, Jukka T.
AU - Stehouwer, Coen D A
AU - Tuomainen, Tomi-Pekka
AU - Bots, Michiel L.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Aims: Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population. Methods: Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption. Results: The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming >10 g per day, after adjusting for a range of confounding factors. Conclusion: In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.
AB - Aims: Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population. Methods: Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption. Results: The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming >10 g per day, after adjusting for a range of confounding factors. Conclusion: In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.
UR - http://www.scopus.com/inward/record.url?scp=85021773416&partnerID=8YFLogxK
U2 - 10.1093/alcalc/agx028
DO - 10.1093/alcalc/agx028
M3 - Article
C2 - 28525540
AN - SCOPUS:85021773416
VL - 52
SP - 483
EP - 486
JO - Alcohol and Alcoholism
JF - Alcohol and Alcoholism
SN - 0735-0414
IS - 4
ER -