Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

Susan Peters, Valentina Gallo, Paolo Vineis, Lefkos T. Middleton, Lars Forsgren, Carlotta Sacerdote, Sabina Sieri, Andreas Kyrozis, María Dolores Chirlaque, Raul Zamora-Ros, Oskar Hansson, Jesper Petersson, Verena Katzke, Tilman Kühn, Olatz Mokoroa, Giovanna Masala, Eva Ardanaz, Salvatore Panico, Manuela M. Bergmann, Timothy J. KeyElisabete Weiderpass, Pietro Ferrari, Roel Vermeulen

Research output: Contribution to journalArticlepeer-review

10 Citations (SciVal)

Abstract

Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.

Original languageEnglish
Pages (from-to)1258-1263
Number of pages6
JournalMovement Disorders
Volume35
Issue number7
Early online date2020 May 1
DOIs
Publication statusPublished - 2020 Jul

Subject classification (UKÄ)

  • Public Health, Global Health, Social Medicine and Epidemiology
  • Neurology

Keywords

  • alcohol
  • EPIC
  • epidemiology
  • Parkinson
  • prospective cohort

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