Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

Alaa M. G. Ali; Marjanka K. Schmidt; Manjeet K. Bolla; Qin Wang; M. Gago-Dominguez; J. Esteban Castelao; Angel Carracedo; Victor Munoz Garzon; Stig E. Bojesen; Borge G. Nordestgaard; Henrik Flyger; Jenny Chang-Claude; Alina Vrieling; Anja Rudolph; Petra Seibold; Heli Nevanlinna; Taru A. Muranen; Kirsimari Aaltonen; Carl Blomqvist; Keitaro Matsuo; Hidemi Ito; Hiroji Iwata; Akiyo Horio; Esther M. John; Mark Sherman; Jolanta Lissowska; Jonine Figueroa; Montserrat Garcia-Closas; Hoda Anton-Culver; Mitul Shah; John L. Hopper; Antonia Trichopoulou; Bas Bueno-de-Mesquita; Vittorio Krogh; Elisabete Weiderpass; Anne Andersson; Francoise Clavel-Chapelon; Laure Dossus; Guy Fagherazzi; Petra H. Peeters; Anja Olsen; Gordon C. Wishart; Douglas F. Easton; Signe Borgquist; Kim Overvad; Aurelio Barricarte; Carlos A. Gonzalez; Maria-Jose Sanchez; Pilar Amiano; Elio Riboli; Tim Key; Paul D. Pharoah

doi:10.1158/1055-9965.EPI-13-0901

Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

Alaa M. G. Ali, Marjanka K. Schmidt, Manjeet K. Bolla, Qin Wang, M. Gago-Dominguez, J. Esteban Castelao, Angel Carracedo, Victor Munoz Garzon, Stig E. Bojesen, Borge G. Nordestgaard, Henrik Flyger, Jenny Chang-Claude, Alina Vrieling, Anja Rudolph, Petra Seibold, Heli Nevanlinna, Taru A. Muranen, Kirsimari Aaltonen, Carl Blomqvist, Keitaro MatsuoHidemi Ito, Hiroji Iwata, Akiyo Horio, Esther M. John, Mark Sherman, Jolanta Lissowska, Jonine Figueroa, Montserrat Garcia-Closas, Hoda Anton-Culver, Mitul Shah, John L. Hopper, Antonia Trichopoulou, Bas Bueno-de-Mesquita, Vittorio Krogh, Elisabete Weiderpass, Anne Andersson, Francoise Clavel-Chapelon, Laure Dossus, Guy Fagherazzi, Petra H. Peeters, Anja Olsen, Gordon C. Wishart, Douglas F. Easton, Signe Borgquist, Kim Overvad, Aurelio Barricarte, Carlos A. Gonzalez, Maria-Jose Sanchez, Pilar Amiano, Elio Riboli, Tim Key, Paul D. Pharoah

Breastcancer-genetics

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre-or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. (C) 2014 AACR.

Original language	English
Pages (from-to)	934-945
Journal	Cancer Epidemiology Biomarkers & Prevention
Volume	23
Issue number	6
DOIs	https://doi.org/10.1158/1055-9965.EPI-13-0901
Publication status	Published - 2014

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Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1055-9965.EPI-13-0901

Cite this

Ali, A. M. G., Schmidt, M. K., Bolla, M. K., Wang, Q., Gago-Dominguez, M., Esteban Castelao, J., Carracedo, A., Munoz Garzon, V., Bojesen, S. E., Nordestgaard, B. G., Flyger, H., Chang-Claude, J., Vrieling, A., Rudolph, A., Seibold, P., Nevanlinna, H., Muranen, T. A., Aaltonen, K., Blomqvist, C., ... Pharoah, P. D. (2014). Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases. Cancer Epidemiology Biomarkers & Prevention, 23(6), 934-945. https://doi.org/10.1158/1055-9965.EPI-13-0901

@article{4179cc515ed840f881d89b7f3602c0b9,

title = "Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases",

abstract = "Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for {"}moderate drinkers{"} versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre-or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. (C) 2014 AACR.",

author = "Ali, {Alaa M. G.} and Schmidt, {Marjanka K.} and Bolla, {Manjeet K.} and Qin Wang and M. Gago-Dominguez and {Esteban Castelao}, J. and Angel Carracedo and {Munoz Garzon}, Victor and Bojesen, {Stig E.} and Nordestgaard, {Borge G.} and Henrik Flyger and Jenny Chang-Claude and Alina Vrieling and Anja Rudolph and Petra Seibold and Heli Nevanlinna and Muranen, {Taru A.} and Kirsimari Aaltonen and Carl Blomqvist and Keitaro Matsuo and Hidemi Ito and Hiroji Iwata and Akiyo Horio and John, {Esther M.} and Mark Sherman and Jolanta Lissowska and Jonine Figueroa and Montserrat Garcia-Closas and Hoda Anton-Culver and Mitul Shah and Hopper, {John L.} and Antonia Trichopoulou and Bas Bueno-de-Mesquita and Vittorio Krogh and Elisabete Weiderpass and Anne Andersson and Francoise Clavel-Chapelon and Laure Dossus and Guy Fagherazzi and Peeters, {Petra H.} and Anja Olsen and Wishart, {Gordon C.} and Easton, {Douglas F.} and Signe Borgquist and Kim Overvad and Aurelio Barricarte and Gonzalez, {Carlos A.} and Maria-Jose Sanchez and Pilar Amiano and Elio Riboli and Tim Key and Pharoah, {Paul D.}",

year = "2014",

doi = "10.1158/1055-9965.EPI-13-0901",

language = "English",

volume = "23",

pages = "934--945",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1538-7755",

publisher = "American Association for Cancer Research",

number = "6",

}

Ali, AMG, Schmidt, MK, Bolla, MK, Wang, Q, Gago-Dominguez, M, Esteban Castelao, J, Carracedo, A, Munoz Garzon, V, Bojesen, SE, Nordestgaard, BG, Flyger, H, Chang-Claude, J, Vrieling, A, Rudolph, A, Seibold, P, Nevanlinna, H, Muranen, TA, Aaltonen, K, Blomqvist, C, Matsuo, K, Ito, H, Iwata, H, Horio, A, John, EM, Sherman, M, Lissowska, J, Figueroa, J, Garcia-Closas, M, Anton-Culver, H, Shah, M, Hopper, JL, Trichopoulou, A, Bueno-de-Mesquita, B, Krogh, V, Weiderpass, E, Andersson, A, Clavel-Chapelon, F, Dossus, L, Fagherazzi, G, Peeters, PH, Olsen, A, Wishart, GC, Easton, DF, Borgquist, S, Overvad, K, Barricarte, A, Gonzalez, CA, Sanchez, M-J, Amiano, P, Riboli, E, Key, T & Pharoah, PD 2014, 'Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases', Cancer Epidemiology Biomarkers & Prevention, vol. 23, no. 6, pp. 934-945. https://doi.org/10.1158/1055-9965.EPI-13-0901

TY - JOUR

T1 - Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

AU - Ali, Alaa M. G.

AU - Schmidt, Marjanka K.

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Gago-Dominguez, M.

AU - Esteban Castelao, J.

AU - Carracedo, Angel

AU - Munoz Garzon, Victor

AU - Bojesen, Stig E.

AU - Nordestgaard, Borge G.

AU - Flyger, Henrik

AU - Chang-Claude, Jenny

AU - Vrieling, Alina

AU - Rudolph, Anja

AU - Seibold, Petra

AU - Nevanlinna, Heli

AU - Muranen, Taru A.

AU - Aaltonen, Kirsimari

AU - Blomqvist, Carl

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Iwata, Hiroji

AU - Horio, Akiyo

AU - John, Esther M.

AU - Sherman, Mark

AU - Lissowska, Jolanta

AU - Figueroa, Jonine

AU - Garcia-Closas, Montserrat

AU - Anton-Culver, Hoda

AU - Shah, Mitul

AU - Hopper, John L.

AU - Trichopoulou, Antonia

AU - Bueno-de-Mesquita, Bas

AU - Krogh, Vittorio

AU - Weiderpass, Elisabete

AU - Andersson, Anne

AU - Clavel-Chapelon, Francoise

AU - Dossus, Laure

AU - Fagherazzi, Guy

AU - Peeters, Petra H.

AU - Olsen, Anja

AU - Wishart, Gordon C.

AU - Easton, Douglas F.

AU - Borgquist, Signe

AU - Overvad, Kim

AU - Barricarte, Aurelio

AU - Gonzalez, Carlos A.

AU - Sanchez, Maria-Jose

AU - Amiano, Pilar

AU - Riboli, Elio

AU - Key, Tim

AU - Pharoah, Paul D.

PY - 2014

Y1 - 2014

N2 - Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre-or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. (C) 2014 AACR.

AB - Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre-or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. (C) 2014 AACR.

U2 - 10.1158/1055-9965.EPI-13-0901

DO - 10.1158/1055-9965.EPI-13-0901

M3 - Article

C2 - 24636975

SN - 1538-7755

VL - 23

SP - 934

EP - 945

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

IS - 6

ER -

Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

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