Abstract
Specific binding of aldosterone by crude membrane fraction, the affinity and maximal concentration of cytosolic receptors of aldosterone were studied in the kidney cortex of the Wistar rats as well as the plasma level and adrenal biosynthesis of aldosterone. The specific binding of aldosterone was found to increase in membrane fraction and to decrease in cytosol during kidney maturation. The affinity of the cytosol receptors to aldosterone did not change in the same period. The level of biosynthesis in adrenals and plasma concentration of aldosterone was higher in adult rather than in young rats. The membrane binding of aldosterone seems to take part in the mechanism of cell sensitivity to aldosterone.
| Original language | English |
|---|---|
| Pages (from-to) | 251-6 |
| Journal | Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova |
| Volume | 75 |
| Issue number | 2 |
| Publication status | Published - 1989 |
| Externally published | Yes |
Subject classification (UKÄ)
- Clinical Medicine
Free keywords
- Adrenal Glands/metabolism
- Aging/metabolism
- Aldosterone/analysis
- Animals
- Cell Membrane/metabolism
- Cytosol/metabolism
- Kidney/metabolism
- Male
- Rats
- Rats, Inbred Strains
- Receptors, Glucocorticoid/analysis
- Receptors, Mineralocorticoid
- Tritium