Amino acids predict prognosis in patients with acute dyspnea

Karolin Wiklund, Klas Gränsbo, Peter Almgren, Marjaneh Peyman, Lena Tegnér, Maria Toni-Bengtsson, Mattias Wieloch, Olle Melander

Research output: Contribution to journalArticlepeer-review


Background: To identify amino acids that can predict risk of 90-day mortality in patients with acute dyspnea. Method: Plasma levels of nine amino acids were analyzed 663 adult patients admitted to the Emergency Department (ED) with acute dyspnea. Cox proportional hazards models were used to examine the relation between amino acid levels and the risk of 90-day mortality. Result: Eighty patients (12.1%) died within 90 days of admission. An “Amino Acid Mortality Risk Score” (AMRS), summing absolute plasma levels of glycine, phenylalanine and valine, demonstrated that among the patients belonging to quartile 1 (Q1) of the AMRS, only 4 patients died, compared to 44 patients in quartile 4. Using Q1 of the AMRS as reference, each increment of 1 SD in the AMRS was associated with a hazard ratio (HR) of 2.15 for 90-day mortality, and the HR was > 9 times higher in Q4. Conclusion: Glycine, phenylalanine and valine are associated with a risk of 90-day mortality in patients admitted to the ED for acute dyspnea, suggesting that these amino acids may be useful in risk assessments.

Original languageEnglish
Article number127
JournalBMC Emergency Medicine
Issue number1
Publication statusPublished - 2021 Dec

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

Free keywords

  • Amino acids
  • Dyspnea
  • Emergency service, hospital
  • Glycine
  • Phenylalanine
  • Valine


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