An agnostic study of associations between abo and rhd blood group and phenome-wide disease risk

Torsten Dahlén, Mark Clements, Jingcheng Zhao, Martin L. Olsson, Gustaf Edgren

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. Results: We discovered 49 and 1 associations between a disease and ABO and RhD blood group, respectively, after adjustment for multiple testing. We identified new associations such as kidney stones and blood group B as compared to O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood group A and AB as compared to O and RhD positive as compared to negative. Conclusion: Our findings generate strong further support for previously known associations, but also indicate new interesting relations.

Original languageEnglish
Article numbere65658
JournaleLife
Volume10
DOIs
Publication statusPublished - 2021 Apr 27

Subject classification (UKÄ)

  • Public Health, Global Health, Social Medicine and Epidemiology

Keywords

  • ABO
  • Agnostic
  • Disease occurrence
  • Phenome-wide study
  • RhD

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