An electrochemical-cantilever hybrid sensor for metal ions

Lee MacKenzie Fischer; S. Dohn; Anja Boisen; Maria Tenje

doi:10.1109/ICSENS.2010.5690884

An electrochemical-cantilever hybrid sensor for metal ions

Lee MacKenzie Fischer, S. Dohn, Anja Boisen, Maria Tenje

External Organization - Unknown

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

Abstract

In this work we have demonstrated a peptide functionalized cantilever sensor with integrated electrochemical capabilities. Silicon nitride cantilevers with gold electrodes are functionalized with the chelating peptide Cys-Gly-Gly-His (CGGH) to capture Cu2+ ions from solution. Upon binding the copper ion the peptide folds, creating steric hindrance and causing compressive stress in the monolayer, deflecting the cantilever downward. Ethylenediaminetetraacetic acid (EDTA) was used to remove the copper ions from the peptide, regenerating the layer. A Cysteine monolayer deflected the cantilever upward with Cu2+ ions, indicating tensile stress in the layer, suggesting a different coordination scheme than the CGGH peptide layer.

Original language	English
Title of host publication	[Host publication title missing]
Publisher	IEEE - Institute of Electrical and Electronics Engineers Inc.
Pages	913-917
ISBN (Print)	978-1-4244-8170-5
DOIs	https://doi.org/10.1109/ICSENS.2010.5690884
Publication status	Published - 2010
Externally published	Yes
Event	IEEE Sensors - Waikoloa, United States Duration: 2010 Nov 1 → 2010 Nov 4

Conference

Conference	IEEE Sensors
Country/Territory	United States
City	Waikoloa
Period	2010/11/01 → 2010/11/04

Subject classification (UKÄ)

Medical Engineering

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10.1109/ICSENS.2010.5690884

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@inproceedings{474c4f4df77e4d5e93ac5fcf97580f2c,

title = "An electrochemical-cantilever hybrid sensor for metal ions",

abstract = "In this work we have demonstrated a peptide functionalized cantilever sensor with integrated electrochemical capabilities. Silicon nitride cantilevers with gold electrodes are functionalized with the chelating peptide Cys-Gly-Gly-His (CGGH) to capture Cu2+ ions from solution. Upon binding the copper ion the peptide folds, creating steric hindrance and causing compressive stress in the monolayer, deflecting the cantilever downward. Ethylenediaminetetraacetic acid (EDTA) was used to remove the copper ions from the peptide, regenerating the layer. A Cysteine monolayer deflected the cantilever upward with Cu2+ ions, indicating tensile stress in the layer, suggesting a different coordination scheme than the CGGH peptide layer.",

author = "Fischer, \{Lee MacKenzie\} and S. Dohn and Anja Boisen and Maria Tenje",

year = "2010",

doi = "10.1109/ICSENS.2010.5690884",

language = "English",

isbn = "978-1-4244-8170-5",

pages = "913--917",

booktitle = "[Host publication title missing]",

publisher = "IEEE - Institute of Electrical and Electronics Engineers Inc.",

address = "United States",

note = "IEEE Sensors ; Conference date: 01-11-2010 Through 04-11-2010",

}

TY - GEN

T1 - An electrochemical-cantilever hybrid sensor for metal ions

AU - Fischer, Lee MacKenzie

AU - Dohn, S.

AU - Boisen, Anja

AU - Tenje, Maria

PY - 2010

Y1 - 2010

N2 - In this work we have demonstrated a peptide functionalized cantilever sensor with integrated electrochemical capabilities. Silicon nitride cantilevers with gold electrodes are functionalized with the chelating peptide Cys-Gly-Gly-His (CGGH) to capture Cu2+ ions from solution. Upon binding the copper ion the peptide folds, creating steric hindrance and causing compressive stress in the monolayer, deflecting the cantilever downward. Ethylenediaminetetraacetic acid (EDTA) was used to remove the copper ions from the peptide, regenerating the layer. A Cysteine monolayer deflected the cantilever upward with Cu2+ ions, indicating tensile stress in the layer, suggesting a different coordination scheme than the CGGH peptide layer.

AB - In this work we have demonstrated a peptide functionalized cantilever sensor with integrated electrochemical capabilities. Silicon nitride cantilevers with gold electrodes are functionalized with the chelating peptide Cys-Gly-Gly-His (CGGH) to capture Cu2+ ions from solution. Upon binding the copper ion the peptide folds, creating steric hindrance and causing compressive stress in the monolayer, deflecting the cantilever downward. Ethylenediaminetetraacetic acid (EDTA) was used to remove the copper ions from the peptide, regenerating the layer. A Cysteine monolayer deflected the cantilever upward with Cu2+ ions, indicating tensile stress in the layer, suggesting a different coordination scheme than the CGGH peptide layer.

UR - https://www.scopus.com/pages/publications/79951879739

U2 - 10.1109/ICSENS.2010.5690884

DO - 10.1109/ICSENS.2010.5690884

M3 - Paper in conference proceeding

SN - 978-1-4244-8170-5

SP - 913

EP - 917

BT - [Host publication title missing]

PB - IEEE - Institute of Electrical and Electronics Engineers Inc.

T2 - IEEE Sensors

Y2 - 1 November 2010 through 4 November 2010

ER -

An electrochemical-cantilever hybrid sensor for metal ions

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Subject classification (UKÄ)

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