An extract of Uncaria tomentosa inhibiting cell division and NF-kappaB activity without inducing cell death.

Christina Silver, Hanna Lindgren, Ronald Pero, Tomas Leanderson, Fredrik Ivars

Research output: Contribution to journalArticlepeer-review

58 Citations (SciVal)

Abstract

Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100®, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in C-Med 100®-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these data suggested interference with a common pathway controlling cell growth and cell cycle progression. Indeed, we provide direct evidence that C-Med 100® inhibits nuclear factor κB (NF-κB) activity and propose that this at least partially causes the inhibition of proliferation.
Original languageEnglish
Pages (from-to)1889-1900
JournalInternational Immunopharmacology
Volume3
Issue number13-14
DOIs
Publication statusPublished - 2003

Subject classification (UKÄ)

  • Pharmacology and Toxicology

Keywords

  • Inhibition
  • NF-κB
  • Uncaria tomentosa
  • Proliferation
  • Apoptosis

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