An improved probing controller for substrate feeding in fed-batch culteres of E. coli: simulations and experiments

Mats Åkesson, Per Hagander, Jan Peter Axelsson

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

A strategy for feedback control of the glucose feed rate in cultivations of E.coli is discussed. By making probing pulses in the feedrate it is possible to detect and avoid undesirable by-productformation using a standard dissolved oxygen sensor. The feasibility of an improved and simplified probing algorithm is demonstrated by simulations as well as laboratory-scale experiments.
Original languageEnglish
Title of host publicationComputer Applications in Biotechnology 2001
PublisherElsevier
Pages213-218
ISBN (Print)0080436811
Publication statusPublished - 2002
Event8th IFAC International Conference on Computer Applications in Biotechnology (CAB8) - Quebeq City, Canada
Duration: 2001 Jun 242001 Jun 27

Conference

Conference8th IFAC International Conference on Computer Applications in Biotechnology (CAB8)
Country/TerritoryCanada
CityQuebeq City
Period2001/06/242001/06/27

Subject classification (UKÄ)

  • Control Engineering

Keywords

  • Fermentation process
  • probing
  • extremum control
  • process control

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