An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.

Karolina Holm; Johan Staaf; Martin Lauss; Mattias Aine; David Lindgren; Pär-Ola Bendahl; Johan Vallon-Christersson; Rosa Bjork Barkardottir; Mattias Höglund; Åke Borg; Göran B Jönsson; Markus Ringnér

doi:10.1186/s13058-016-0685-5

An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.

Karolina Holm, Johan Staaf, Martin Lauss, Mattias Aine, David Lindgren, Pär-Ola Bendahl, Johan Vallon-Christersson, Rosa Bjork Barkardottir, Mattias Höglund, Åke Borg, Göran B Jönsson, Markus Ringnér

National University Hospital of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Aberrant DNA methylation is frequently observed in breast cancer. However, the relationship between methylation patterns and the heterogeneity of breast cancer has not been comprehensively characterized.

Original language	English
Article number	27
Journal	Breast Cancer Research
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s13058-016-0685-5
Publication status	Published - 2016

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13058-016-0685-5Licence: CC BY

http://www.ncbi.nlm.nih.gov/pubmed/26923702?dopt=Abstract

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Holm, K., Staaf, J., Lauss, M., Aine, M., Lindgren, D., Bendahl, P.-O., Vallon-Christersson, J., Barkardottir, R. B., Höglund, M., Borg, Å., Jönsson, G. B., & Ringnér, M. (2016). An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells. Breast Cancer Research, 18(1), Article 27. https://doi.org/10.1186/s13058-016-0685-5

@article{3efe100f04394b249e3a7820a58ebebb,

title = "An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.",

abstract = "Aberrant DNA methylation is frequently observed in breast cancer. However, the relationship between methylation patterns and the heterogeneity of breast cancer has not been comprehensively characterized.",

author = "Karolina Holm and Johan Staaf and Martin Lauss and Mattias Aine and David Lindgren and P{\"a}r-Ola Bendahl and Johan Vallon-Christersson and Barkardottir, {Rosa Bjork} and Mattias H{\"o}glund and {\AA}ke Borg and J{\"o}nsson, {G{\"o}ran B} and Markus Ringn{\'e}r",

year = "2016",

doi = "10.1186/s13058-016-0685-5",

language = "English",

volume = "18",

journal = "Breast Cancer Research",

issn = "1465-5411",

publisher = "BioMed Central (BMC)",

number = "1",

}

Holm, K, Staaf, J , Lauss, M , Aine, M , Lindgren, D , Bendahl, P-O , Vallon-Christersson, J, Barkardottir, RB, Höglund, M , Borg, Å , Jönsson, GB & Ringnér, M 2016, 'An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.', Breast Cancer Research, vol. 18, no. 1, 27. https://doi.org/10.1186/s13058-016-0685-5

TY - JOUR

T1 - An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.

AU - Holm, Karolina

AU - Staaf, Johan

AU - Lauss, Martin

AU - Aine, Mattias

AU - Lindgren, David

AU - Bendahl, Pär-Ola

AU - Vallon-Christersson, Johan

AU - Barkardottir, Rosa Bjork

AU - Höglund, Mattias

AU - Borg, Åke

AU - Jönsson, Göran B

AU - Ringnér, Markus

PY - 2016

Y1 - 2016

N2 - Aberrant DNA methylation is frequently observed in breast cancer. However, the relationship between methylation patterns and the heterogeneity of breast cancer has not been comprehensively characterized.

AB - Aberrant DNA methylation is frequently observed in breast cancer. However, the relationship between methylation patterns and the heterogeneity of breast cancer has not been comprehensively characterized.

U2 - 10.1186/s13058-016-0685-5

DO - 10.1186/s13058-016-0685-5

M3 - Article

C2 - 26923702

SN - 1465-5411

VL - 18

JO - Breast Cancer Research

JF - Breast Cancer Research

IS - 1

M1 - 27

ER -

An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.

Abstract

Subject classification (UKÄ)

UN SDGs

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