Anabolic and antiresorptive actions of locally delivered bisphosphonates for bone repair

I. Qayoom, D. B. Raina, A. Širka, Tarasevičius, M. Tägil, A. Kumar, L. Lidgren

Research output: Contribution to journalReview articlepeer-review


During the last decades, several research groups have used bisphosphonates for local application to counteract secondary bone resorption after bone grafting, to improve implant fixation or to control bone resorption caused by bone morphogenetic proteins (BMps). We focused on zoledronate (a bisphosphonate) due to its greater antiresorptive potential over other bisphosphonates. Recently, it has become obvious that the carrier is of importance to modulate the concentration and elution profile of the zoledronic acid locally. Incorporating one fifth of the recommended systemic dose of zoledronate with different apatite matrices and types of bone defects has been shown to enhance bone regeneration significantly in vivo. We expect the local delivery of zoledronate to overcome the limitations and side effects associated with systemic usage; however, we need to know more about the bioavailability and the biological effects. The local use of BMp-2 and zoledronate as a combination has a proven additional effect on bone regeneration. This review focuses primarily on the local use of zoledronate alone, or in combination with bone anabolic factors, in various preclinical models mimicking different orthopaedic conditions.

Original languageEnglish
Pages (from-to)548-560
Number of pages13
JournalBone and Joint Research
Issue number10
Publication statusPublished - 2018 Oct 3

Subject classification (UKÄ)

  • Orthopedics

Free keywords

  • Bisphosphonates
  • Bone repair
  • Carrier
  • Ceramic
  • Local delivery
  • Zoledronic acid


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