Analgesic antipyretic use among young children in the TEDDY study: No association with islet autoimmunity

Markus Lundgren; Leigh Johnson Steed; Roy N. Tamura; Berglind Jonsdottir; Patricia Gesualdo; Claire Cowen Crouch; Maija Sjöberg; Gertie Hansson; William A. Hagopian; Anette-G Ziegler; Marian J. Rewers; Åke Lernmark; Jorma Toppari; Jin-Xiong She; Beena Akolkar; Jeffrey P. Krischer; Michael J. Haller; Helena Elding Larsson; Kimberly Bautista; Judith Baxter; Ruth Bedoy; Daniel Felipe-Morales; Kimberly Driscoll; Brigitte I. Frohnert; Michelle Hoffman; Rachel Karban; Edwin Liu; Jill Norris; Adela Samper-Imaz; Andrea K Steck; Kathleen Waugh; Hali Wright; Olli G. Simell; Annika Adamsson; Suvi Ahonen; Heikki Hyöty; Jorma Ilonen; Sanna Jokipuu; Tiina Kallio; Leena Karlsson; Miia Kähönen; Mikael Knip; Lea Kovanen; Mirva Koreasalo; Kalle Kurppa; Tiina Latvaaho; Maria Lönnrot; Elina Mäntymäki; Katja Multasuo; Juha Mykkänen; Tiina Niininen; Sari Niinistö; Mia Nyblom; Petra Rajala; Jenna Rautanen; Anne Riikonen; Mika Riikonen; Jenni Rouhiainen; Minna Romo; Tuula Simell; Ville Simell; Aino Stenius; Maria Leppänen; Sini Vainionpää; Eeva Varjonen; Riitta Veijola; Suvi M Virtanen; Mari Vähä-Mäkilä; Mari Åkerlund; Katri Lindfors; Desmond Schatz; Diane Hopkins; Jamie Thomas; Janey Adams; Katherine Silvis; Melissa Gardiner; Richard McIndoe; Ashok Sharma; Joshua W Williams; Gabriela Young; Stephen W. Anderson; Laura Mary Jacobsen; Andreas Beyerlein; Ezio Bonifacio; Michael Hummel; Sandra Hummel; Kristina Foterek; Nicole Janz; Mathilde Kersting; Annette Knopff; Sibylle Koletzko; Claudia Peplow; Roswith Roth; Marlon Scholz; Joanna Stock; Katharina Warncke; Lorena Wendel; Christiane Winkler; Daniel Agardh; Carin Andrén Aronsson; Maria Ask; Jenny Bremer; Ulla Marie Carlsson; Corrado Cilio; Emelie Ericson-Hallström; Lina Fransson; Thomas Gard; Joanna Gerardsson; Rasmus Bennet; Monica Hansen; Susanne Hyberg; Fredrik Johansen; Marielle Lindström; Maria Månsson-Martinez; Maria Markan; Jessica Melin; Zeliha Mestan; Karin Ottosson; Kobra Rahmati; Anita Ramelius; Falastin Salami; Sara Sibthorpe; Birgitta Sjöberg; Ulrica Swartling; Evelyn Tekum Amboh; Carina Törn; Anne Wallin; Åsa Wimar; Sofie Åberg; Killian Michael Killian; Jennifer Skidmore; Josephine Carson; Maria Dalzell; Kayleen Dunson; Rachel Hervey; Corbin Johnson; Rachel Lyons; Arlene Meyer; Denise Mulenga; Alexander Tarr; Morgan Uland; John Willis; Dorothy Becker; Margaret Franciscus; Mary Ellen; Mary Ellen Dalmagro Elias Smith; Ashi Daftary; Mary Beth Klein; Chrystal Yates; Michael Abbondondolo; Sarah Austin-Gonzalez; Maryouri Avendano; Sandra Baethke; Rasheedah Brown; Brant R. Burkhardt; Martha Butterworth; Joanna Clasen; David Cuthbertson; Eberhard Christopher Eberhard; Steven W. Fiske; Dena Garcia; Jennifer Garmeson; Veena Gowda; Kathleen Heyman; Francisco Perez Laras; Hye-Seung Lee; Shu Liu; Xiang Liu; Kristian Lynch; Jamie Malloy; Cristina McCarthy; Steven Meulemans; Hemang Parikh; Chris Shaffer; Laura Smith; Susan Smith; Noah Sulman; Ulla Uusitalo; Kendra Vehik; Ponni Vijayakandipan; Keith Wood; Jimin Yang; R. D. Lori Ballard; David Hadley; Wendy Mcleod; Liping Yu; Dongmei Miao; Polly J Bingley; Alistair Williams; Kyla Chandler; Saba Rokni; Claire L. Williams; Rebecca Wyatt; Gifty George; Sian Grace; Henry Erlich; Steven J. Mack; Anna Lisa Fear; Sandra Ke; Niveen Mulholland; Stephen Rich; Wei-Min Chen; Suna Onengut-Gumuscu; Emily Farber; Rebecca Roche Pickin; Jordan Davis; Dan Gallo; Jessica Bonnie; Paul Campolieto; Kasia Bourcier; Thomas Briese; Suzanne Bennett Johnson; Eric W Triplett

doi:10.1186/s12887-017-0884-y

Analgesic antipyretic use among young children in the TEDDY study: No association with islet autoimmunity

Markus Lundgren, Leigh Johnson Steed, Roy N. Tamura, Berglind Jonsdottir, Patricia Gesualdo, Claire Cowen Crouch, Maija Sjöberg, Gertie Hansson, William A. Hagopian, Anette-G Ziegler, Marian J. Rewers, Åke Lernmark, Jorma Toppari, Jin-Xiong She, Beena Akolkar, Jeffrey P. Krischer, Michael J. Haller, Helena Elding Larsson, Kimberly Bautista, Judith BaxterRuth Bedoy, Daniel Felipe-Morales, Kimberly Driscoll, Brigitte I. Frohnert, Michelle Hoffman, Rachel Karban, Edwin Liu, Jill Norris, Adela Samper-Imaz, Andrea K Steck, Kathleen Waugh, Hali Wright, Olli G. Simell, Annika Adamsson, Suvi Ahonen, Heikki Hyöty, Jorma Ilonen, Sanna Jokipuu, Tiina Kallio, Leena Karlsson, Miia Kähönen, Mikael Knip, Lea Kovanen, Mirva Koreasalo, Kalle Kurppa, Tiina Latvaaho, Maria Lönnrot, Elina Mäntymäki, Katja Multasuo, Juha Mykkänen, Tiina Niininen, Sari Niinistö, Mia Nyblom, Petra Rajala, Jenna Rautanen, Anne Riikonen, Mika Riikonen, Jenni Rouhiainen, Minna Romo, Tuula Simell, Ville Simell, Aino Stenius, Maria Leppänen, Sini Vainionpää, Eeva Varjonen, Riitta Veijola, Suvi M Virtanen, Mari Vähä-Mäkilä, Mari Åkerlund, Katri Lindfors, Desmond Schatz, Diane Hopkins, Jamie Thomas, Janey Adams, Katherine Silvis, Melissa Gardiner, Richard McIndoe, Ashok Sharma, Joshua W Williams, Gabriela Young, Stephen W. Anderson, Laura Mary Jacobsen, Andreas Beyerlein, Ezio Bonifacio, Michael Hummel, Sandra Hummel, Kristina Foterek, Nicole Janz, Mathilde Kersting, Annette Knopff, Sibylle Koletzko, Claudia Peplow, Roswith Roth, Marlon Scholz, Joanna Stock, Katharina Warncke, Lorena Wendel, Christiane Winkler, Daniel Agardh, Carin Andrén Aronsson, Maria Ask, Jenny Bremer, Ulla Marie Carlsson, Corrado Cilio, Emelie Ericson-Hallström, Lina Fransson, Thomas Gard, Joanna Gerardsson, Rasmus Bennet, Monica Hansen, Susanne Hyberg, Fredrik Johansen, Marielle Lindström, Maria Månsson-Martinez, Maria Markan, Jessica Melin, Zeliha Mestan, Karin Ottosson, Kobra Rahmati, Anita Ramelius, Falastin Salami, Sara Sibthorpe, Birgitta Sjöberg, Ulrica Swartling, Evelyn Tekum Amboh, Carina Törn, Anne Wallin, Åsa Wimar, Sofie Åberg, Killian Michael Killian, Jennifer Skidmore, Josephine Carson, Maria Dalzell, Kayleen Dunson, Rachel Hervey, Corbin Johnson, Rachel Lyons, Arlene Meyer, Denise Mulenga, Alexander Tarr, Morgan Uland, John Willis, Dorothy Becker, Margaret Franciscus, Mary Ellen, Mary Ellen Dalmagro Elias Smith, Ashi Daftary, Mary Beth Klein, Chrystal Yates, Michael Abbondondolo, Sarah Austin-Gonzalez, Maryouri Avendano, Sandra Baethke, Rasheedah Brown, Brant R. Burkhardt, Martha Butterworth, Joanna Clasen, David Cuthbertson, Eberhard Christopher Eberhard, Steven W. Fiske, Dena Garcia, Jennifer Garmeson, Veena Gowda, Kathleen Heyman, Francisco Perez Laras, Hye-Seung Lee, Shu Liu, Xiang Liu, Kristian Lynch, Jamie Malloy, Cristina McCarthy, Steven Meulemans, Hemang Parikh, Chris Shaffer, Laura Smith, Susan Smith, Noah Sulman, Ulla Uusitalo, Kendra Vehik, Ponni Vijayakandipan, Keith Wood, Jimin Yang, R. D. Lori Ballard, David Hadley, Wendy Mcleod, Liping Yu, Dongmei Miao, Polly J Bingley, Alistair Williams, Kyla Chandler, Saba Rokni, Claire L. Williams, Rebecca Wyatt, Gifty George, Sian Grace, Henry Erlich, Steven J. Mack, Anna Lisa Fear, Sandra Ke, Niveen Mulholland, Stephen Rich, Wei-Min Chen, Suna Onengut-Gumuscu, Emily Farber, Rebecca Roche Pickin, Jordan Davis, Dan Gallo, Jessica Bonnie, Paul Campolieto, Kasia Bourcier, Thomas Briese, Suzanne Bennett Johnson, Eric W Triplett

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.

Original language	English
Article number	127
Journal	BMC Pediatrics
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12887-017-0884-y
Publication status	Published - 2017 May 16

Subject classification (UKÄ)

Endocrinology and Diabetes

Free keywords

Analgesics
Islet autoimmunity
Prospective studies
Type 1 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12887-017-0884-y

Cite this

Lundgren, M., Steed, L. J., Tamura, R. N., Jonsdottir, B., Gesualdo, P., Crouch, C. C., Sjöberg, M., Hansson, G., Hagopian, W. A., Ziegler, A.-G., Rewers, M. J., Lernmark, Å., Toppari, J., She, J.-X., Akolkar, B., Krischer, J. P., Haller, M. J., Elding Larsson, H., Bautista, K., ... Triplett, E. W. (2017). Analgesic antipyretic use among young children in the TEDDY study: No association with islet autoimmunity. BMC Pediatrics, 17(1), Article 127. https://doi.org/10.1186/s12887-017-0884-y

@article{6a59c413936c49088bed26b4774b1f84,

title = "Analgesic antipyretic use among young children in the TEDDY study: No association with islet autoimmunity",

abstract = "Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.",

keywords = "Analgesics, Islet autoimmunity, Prospective studies, Type 1 diabetes",

author = "Markus Lundgren and Steed, {Leigh Johnson} and Tamura, {Roy N.} and Berglind Jonsdottir and Patricia Gesualdo and Crouch, {Claire Cowen} and Maija Sj{\"o}berg and Gertie Hansson and Hagopian, {William A.} and Anette-G Ziegler and Rewers, {Marian J.} and {\AA}ke Lernmark and Jorma Toppari and Jin-Xiong She and Beena Akolkar and Krischer, {Jeffrey P.} and Haller, {Michael J.} and {Elding Larsson}, Helena and Kimberly Bautista and Judith Baxter and Ruth Bedoy and Daniel Felipe-Morales and Kimberly Driscoll and Frohnert, {Brigitte I.} and Michelle Hoffman and Rachel Karban and Edwin Liu and Jill Norris and Adela Samper-Imaz and Steck, {Andrea K} and Kathleen Waugh and Hali Wright and Simell, {Olli G.} and Annika Adamsson and Suvi Ahonen and Heikki Hy{\"o}ty and Jorma Ilonen and Sanna Jokipuu and Tiina Kallio and Leena Karlsson and Miia K{\"a}h{\"o}nen and Mikael Knip and Lea Kovanen and Mirva Koreasalo and Kalle Kurppa and Tiina Latvaaho and Maria L{\"o}nnrot and Elina M{\"a}ntym{\"a}ki and Katja Multasuo and Juha Mykk{\"a}nen and Tiina Niininen and Sari Niinist{\"o} and Mia Nyblom and Petra Rajala and Jenna Rautanen and Anne Riikonen and Mika Riikonen and Jenni Rouhiainen and Minna Romo and Tuula Simell and Ville Simell and Aino Stenius and Maria Lepp{\"a}nen and Sini Vainionp{\"a}{\"a} and Eeva Varjonen and Riitta Veijola and Virtanen, {Suvi M} and Mari V{\"a}h{\"a}-M{\"a}kil{\"a} and Mari {\AA}kerlund and Katri Lindfors and Desmond Schatz and Diane Hopkins and Jamie Thomas and Janey Adams and Katherine Silvis and Melissa Gardiner and Richard McIndoe and Ashok Sharma and Williams, {Joshua W} and Gabriela Young and Anderson, {Stephen W.} and Jacobsen, {Laura Mary} and Andreas Beyerlein and Ezio Bonifacio and Michael Hummel and Sandra Hummel and Kristina Foterek and Nicole Janz and Mathilde Kersting and Annette Knopff and Sibylle Koletzko and Claudia Peplow and Roswith Roth and Marlon Scholz and Joanna Stock and Katharina Warncke and Lorena Wendel and Christiane Winkler and Daniel Agardh and Aronsson, {Carin Andr{\'e}n} and Maria Ask and Jenny Bremer and Carlsson, {Ulla Marie} and Corrado Cilio and Emelie Ericson-Hallstr{\"o}m and Lina Fransson and Thomas Gard and Joanna Gerardsson and Rasmus Bennet and Monica Hansen and Susanne Hyberg and Fredrik Johansen and Marielle Lindstr{\"o}m and Maria M{\aa}nsson-Martinez and Maria Markan and Jessica Melin and Zeliha Mestan and Karin Ottosson and Kobra Rahmati and Anita Ramelius and Falastin Salami and Sara Sibthorpe and Birgitta Sj{\"o}berg and Ulrica Swartling and Amboh, {Evelyn Tekum} and Carina T{\"o}rn and Anne Wallin and {\AA}sa Wimar and Sofie {\AA}berg and {Michael Killian}, Killian and Jennifer Skidmore and Josephine Carson and Maria Dalzell and Kayleen Dunson and Rachel Hervey and Corbin Johnson and Rachel Lyons and Arlene Meyer and Denise Mulenga and Alexander Tarr and Morgan Uland and John Willis and Dorothy Becker and Margaret Franciscus and Mary Ellen and Smith, {Mary Ellen Dalmagro Elias} and Ashi Daftary and Klein, {Mary Beth} and Chrystal Yates and Michael Abbondondolo and Sarah Austin-Gonzalez and Maryouri Avendano and Sandra Baethke and Rasheedah Brown and Burkhardt, {Brant R.} and Martha Butterworth and Joanna Clasen and David Cuthbertson and {Christopher Eberhard}, Eberhard and Fiske, {Steven W.} and Dena Garcia and Jennifer Garmeson and Veena Gowda and Kathleen Heyman and Laras, {Francisco Perez} and Hye-Seung Lee and Shu Liu and Xiang Liu and Kristian Lynch and Jamie Malloy and Cristina McCarthy and Steven Meulemans and Hemang Parikh and Chris Shaffer and Laura Smith and Susan Smith and Noah Sulman and Ulla Uusitalo and Kendra Vehik and Ponni Vijayakandipan and Keith Wood and Jimin Yang and {Lori Ballard}, {R. D.} and David Hadley and Wendy Mcleod and Liping Yu and Dongmei Miao and Bingley, {Polly J} and Alistair Williams and Kyla Chandler and Saba Rokni and Williams, {Claire L.} and Rebecca Wyatt and Gifty George and Sian Grace and Henry Erlich and Mack, {Steven J.} and Fear, {Anna Lisa} and Sandra Ke and Niveen Mulholland and Stephen Rich and Wei-Min Chen and Suna Onengut-Gumuscu and Emily Farber and Pickin, {Rebecca Roche} and Jordan Davis and Dan Gallo and Jessica Bonnie and Paul Campolieto and Kasia Bourcier and Thomas Briese and Johnson, {Suzanne Bennett} and Triplett, {Eric W}",

year = "2017",

month = may,

day = "16",

doi = "10.1186/s12887-017-0884-y",

language = "English",

volume = "17",

journal = "BMC Pediatrics",

issn = "1471-2431",

publisher = "BioMed Central (BMC)",

number = "1",

}

Lundgren, M, Steed, LJ, Tamura, RN, Jonsdottir, B, Gesualdo, P, Crouch, CC, Sjöberg, M, Hansson, G, Hagopian, WA, Ziegler, A-G, Rewers, MJ, Lernmark, Å, Toppari, J, She, J-X, Akolkar, B, Krischer, JP, Haller, MJ, Elding Larsson, H, Bautista, K, Baxter, J, Bedoy, R, Felipe-Morales, D, Driscoll, K, Frohnert, BI, Hoffman, M, Karban, R, Liu, E, Norris, J, Samper-Imaz, A, Steck, AK, Waugh, K, Wright, H, Simell, OG, Adamsson, A, Ahonen, S, Hyöty, H, Ilonen, J, Jokipuu, S, Kallio, T, Karlsson, L, Kähönen, M, Knip, M, Kovanen, L, Koreasalo, M, Kurppa, K, Latvaaho, T, Lönnrot, M, Mäntymäki, E, Multasuo, K, Mykkänen, J, Niininen, T, Niinistö, S, Nyblom, M, Rajala, P, Rautanen, J, Riikonen, A, Riikonen, M, Rouhiainen, J, Romo, M, Simell, T, Simell, V, Stenius, A, Leppänen, M, Vainionpää, S, Varjonen, E, Veijola, R, Virtanen, SM, Vähä-Mäkilä, M, Åkerlund, M, Lindfors, K, Schatz, D, Hopkins, D, Thomas, J, Adams, J, Silvis, K, Gardiner, M, McIndoe, R, Sharma, A, Williams, JW, Young, G, Anderson, SW, Jacobsen, LM, Beyerlein, A, Bonifacio, E, Hummel, M, Hummel, S, Foterek, K, Janz, N, Kersting, M, Knopff, A, Koletzko, S, Peplow, C, Roth, R, Scholz, M, Stock, J, Warncke, K, Wendel, L, Winkler, C, Agardh, D , Aronsson, CA, Ask, M, Bremer, J, Carlsson, UM, Cilio, C , Ericson-Hallström, E, Fransson, L, Gard, T, Gerardsson, J, Bennet, R, Hansen, M, Hyberg, S, Johansen, F, Lindström, M, Månsson-Martinez, M, Markan, M, Melin, J, Mestan, Z, Ottosson, K, Rahmati, K, Ramelius, A, Salami, F, Sibthorpe, S, Sjöberg, B, Swartling, U, Amboh, ET, Törn, C, Wallin, A, Wimar, Å, Åberg, S, Michael Killian, K, Skidmore, J, Carson, J, Dalzell, M, Dunson, K, Hervey, R, Johnson, C, Lyons, R, Meyer, A, Mulenga, D, Tarr, A, Uland, M, Willis, J, Becker, D, Franciscus, M, Ellen, M, Smith, MEDE, Daftary, A, Klein, MB, Yates, C, Abbondondolo, M, Austin-Gonzalez, S, Avendano, M, Baethke, S, Brown, R, Burkhardt, BR, Butterworth, M, Clasen, J, Cuthbertson, D, Christopher Eberhard, E, Fiske, SW, Garcia, D, Garmeson, J, Gowda, V, Heyman, K, Laras, FP, Lee, H-S, Liu, S, Liu, X, Lynch, K, Malloy, J, McCarthy, C, Meulemans, S, Parikh, H, Shaffer, C, Smith, L, Smith, S, Sulman, N, Uusitalo, U, Vehik, K, Vijayakandipan, P, Wood, K, Yang, J, Lori Ballard, RD, Hadley, D, Mcleod, W, Yu, L, Miao, D, Bingley, PJ, Williams, A, Chandler, K, Rokni, S, Williams, CL, Wyatt, R, George, G, Grace, S, Erlich, H, Mack, SJ, Fear, AL, Ke, S, Mulholland, N, Rich, S, Chen, W-M, Onengut-Gumuscu, S, Farber, E, Pickin, RR, Davis, J, Gallo, D, Bonnie, J, Campolieto, P, Bourcier, K, Briese, T, Johnson, SB & Triplett, EW 2017, 'Analgesic antipyretic use among young children in the TEDDY study: No association with islet autoimmunity', BMC Pediatrics, vol. 17, no. 1, 127. https://doi.org/10.1186/s12887-017-0884-y

TY - JOUR

T1 - Analgesic antipyretic use among young children in the TEDDY study

T2 - No association with islet autoimmunity

AU - Lundgren, Markus

AU - Steed, Leigh Johnson

AU - Tamura, Roy N.

AU - Jonsdottir, Berglind

AU - Gesualdo, Patricia

AU - Crouch, Claire Cowen

AU - Sjöberg, Maija

AU - Hansson, Gertie

AU - Hagopian, William A.

AU - Ziegler, Anette-G

AU - Rewers, Marian J.

AU - Lernmark, Åke

AU - Toppari, Jorma

AU - She, Jin-Xiong

AU - Akolkar, Beena

AU - Krischer, Jeffrey P.

AU - Haller, Michael J.

AU - Elding Larsson, Helena

AU - Bautista, Kimberly

AU - Baxter, Judith

AU - Bedoy, Ruth

AU - Felipe-Morales, Daniel

AU - Driscoll, Kimberly

AU - Frohnert, Brigitte I.

AU - Hoffman, Michelle

AU - Karban, Rachel

AU - Liu, Edwin

AU - Norris, Jill

AU - Samper-Imaz, Adela

AU - Steck, Andrea K

AU - Waugh, Kathleen

AU - Wright, Hali

AU - Simell, Olli G.

AU - Adamsson, Annika

AU - Ahonen, Suvi

AU - Hyöty, Heikki

AU - Ilonen, Jorma

AU - Jokipuu, Sanna

AU - Kallio, Tiina

AU - Karlsson, Leena

AU - Kähönen, Miia

AU - Knip, Mikael

AU - Kovanen, Lea

AU - Koreasalo, Mirva

AU - Kurppa, Kalle

AU - Latvaaho, Tiina

AU - Lönnrot, Maria

AU - Mäntymäki, Elina

AU - Multasuo, Katja

AU - Mykkänen, Juha

AU - Niininen, Tiina

AU - Niinistö, Sari

AU - Nyblom, Mia

AU - Rajala, Petra

AU - Rautanen, Jenna

AU - Riikonen, Anne

AU - Riikonen, Mika

AU - Rouhiainen, Jenni

AU - Romo, Minna

AU - Simell, Tuula

AU - Simell, Ville

AU - Stenius, Aino

AU - Leppänen, Maria

AU - Vainionpää, Sini

AU - Varjonen, Eeva

AU - Veijola, Riitta

AU - Virtanen, Suvi M

AU - Vähä-Mäkilä, Mari

AU - Åkerlund, Mari

AU - Lindfors, Katri

AU - Schatz, Desmond

AU - Hopkins, Diane

AU - Thomas, Jamie

AU - Adams, Janey

AU - Silvis, Katherine

AU - Gardiner, Melissa

AU - McIndoe, Richard

AU - Sharma, Ashok

AU - Williams, Joshua W

AU - Young, Gabriela

AU - Anderson, Stephen W.

AU - Jacobsen, Laura Mary

AU - Beyerlein, Andreas

AU - Bonifacio, Ezio

AU - Hummel, Michael

AU - Hummel, Sandra

AU - Foterek, Kristina

AU - Janz, Nicole

AU - Kersting, Mathilde

AU - Knopff, Annette

AU - Koletzko, Sibylle

AU - Peplow, Claudia

AU - Roth, Roswith

AU - Scholz, Marlon

AU - Stock, Joanna

AU - Warncke, Katharina

AU - Wendel, Lorena

AU - Winkler, Christiane

AU - Agardh, Daniel

AU - Aronsson, Carin Andrén

AU - Ask, Maria

AU - Bremer, Jenny

AU - Carlsson, Ulla Marie

AU - Cilio, Corrado

AU - Ericson-Hallström, Emelie

AU - Fransson, Lina

AU - Gard, Thomas

AU - Gerardsson, Joanna

AU - Bennet, Rasmus

AU - Hansen, Monica

AU - Hyberg, Susanne

AU - Johansen, Fredrik

AU - Lindström, Marielle

AU - Månsson-Martinez, Maria

AU - Markan, Maria

AU - Melin, Jessica

AU - Mestan, Zeliha

AU - Ottosson, Karin

AU - Rahmati, Kobra

AU - Ramelius, Anita

AU - Salami, Falastin

AU - Sibthorpe, Sara

AU - Sjöberg, Birgitta

AU - Swartling, Ulrica

AU - Amboh, Evelyn Tekum

AU - Törn, Carina

AU - Wallin, Anne

AU - Wimar, Åsa

AU - Åberg, Sofie

AU - Michael Killian, Killian

AU - Skidmore, Jennifer

AU - Carson, Josephine

AU - Dalzell, Maria

AU - Dunson, Kayleen

AU - Hervey, Rachel

AU - Johnson, Corbin

AU - Lyons, Rachel

AU - Meyer, Arlene

AU - Mulenga, Denise

AU - Tarr, Alexander

AU - Uland, Morgan

AU - Willis, John

AU - Becker, Dorothy

AU - Franciscus, Margaret

AU - Ellen, Mary

AU - Smith, Mary Ellen Dalmagro Elias

AU - Daftary, Ashi

AU - Klein, Mary Beth

AU - Yates, Chrystal

AU - Abbondondolo, Michael

AU - Austin-Gonzalez, Sarah

AU - Avendano, Maryouri

AU - Baethke, Sandra

AU - Brown, Rasheedah

AU - Burkhardt, Brant R.

AU - Butterworth, Martha

AU - Clasen, Joanna

AU - Cuthbertson, David

AU - Christopher Eberhard, Eberhard

AU - Fiske, Steven W.

AU - Garcia, Dena

AU - Garmeson, Jennifer

AU - Gowda, Veena

AU - Heyman, Kathleen

AU - Laras, Francisco Perez

AU - Lee, Hye-Seung

AU - Liu, Shu

AU - Liu, Xiang

AU - Lynch, Kristian

AU - Malloy, Jamie

AU - McCarthy, Cristina

AU - Meulemans, Steven

AU - Parikh, Hemang

AU - Shaffer, Chris

AU - Smith, Laura

AU - Smith, Susan

AU - Sulman, Noah

AU - Uusitalo, Ulla

AU - Vehik, Kendra

AU - Vijayakandipan, Ponni

AU - Wood, Keith

AU - Yang, Jimin

AU - Lori Ballard, R. D.

AU - Hadley, David

AU - Mcleod, Wendy

AU - Yu, Liping

AU - Miao, Dongmei

AU - Bingley, Polly J

AU - Williams, Alistair

AU - Chandler, Kyla

AU - Rokni, Saba

AU - Williams, Claire L.

AU - Wyatt, Rebecca

AU - George, Gifty

AU - Grace, Sian

AU - Erlich, Henry

AU - Mack, Steven J.

AU - Fear, Anna Lisa

AU - Ke, Sandra

AU - Mulholland, Niveen

AU - Rich, Stephen

AU - Chen, Wei-Min

AU - Onengut-Gumuscu, Suna

AU - Farber, Emily

AU - Pickin, Rebecca Roche

AU - Davis, Jordan

AU - Gallo, Dan

AU - Bonnie, Jessica

AU - Campolieto, Paul

AU - Bourcier, Kasia

AU - Briese, Thomas

AU - Johnson, Suzanne Bennett

AU - Triplett, Eric W

PY - 2017/5/16

Y1 - 2017/5/16

N2 - Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.

AB - Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.

KW - Analgesics

KW - Islet autoimmunity

KW - Prospective studies

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85019465441&partnerID=8YFLogxK

U2 - 10.1186/s12887-017-0884-y

DO - 10.1186/s12887-017-0884-y

M3 - Article

C2 - 28511706

AN - SCOPUS:85019465441

SN - 1471-2431

VL - 17

JO - BMC Pediatrics

JF - BMC Pediatrics

IS - 1

M1 - 127

ER -

Analgesic antipyretic use among young children in the TEDDY study: No association with islet autoimmunity

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Preventing the Predictable. Type 1 diabetes in children: Risk factors and impact of participation in prospective follow-up

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