Analysis of a digital clock for molecular computing

Johan Ugander, Mary J. Dunlop, Richard M. Murray

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

The control of synthetic genetic regulatory networks is an emerging engineering challenge. In this study, we propose a new synthetic genetic network that behaves as a digital clock, producing square waveform oscillations. We analyze two models of the network: a deterministic model based on Michaelis-Menten kinetics, as well as a stochastic model based on the Gillespie algorithm. Both models predict regions of oscillatory behavior; the deterministic model provides insight into the conditions required to produce the oscillating clock-like behavior, while the stochastic model is truer to natural dynamics. Intracellular stochasticity is seen to contribute phase noise to the oscillator, and we propose improvements for the network and discuss the conceptual foundations of these improvements.
Original languageEnglish
Title of host publicationAmerican Control Conference, 2007, vols 1-13
PublisherIEEE - Institute of Electrical and Electronics Engineers Inc.
Pages2678-2682
ISBN (Print)1-4244-0988-8
DOIs
Publication statusPublished - 2007
EventAmerican Control Conference, 2007 - New York, New York, NY, United States
Duration: 2007 Jul 112007 Jul 13
Conference number: 26

Publication series

Name
ISSN (Print)0743-1619

Conference

ConferenceAmerican Control Conference, 2007
Abbreviated titleACC´07
Country/TerritoryUnited States
CityNew York, NY
Period2007/07/112007/07/13

Subject classification (UKÄ)

  • Control Engineering

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