Ankylosing Spondylitis Susceptibility and Severity-Contribution of TNF Gene Promoter Polymorphisms at Positions-238 and-308

Elsa Sousa, Joana Caetano-Lopes, Patricia Pinto, Fernando Pimentel, José Teles, Helena Canhao, Ana Rodrigues, Catarina Resende, Ana Filipa Mourao, Celia Ribeiro, Teresa Laura Pinto, Carlos Miranda Rosa, Jose Alberto Pereira da Silva, Jaime Branco, Francisco Ventura, Mario Viana Queiroz, Joao Eurico Fonseca

    Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

    Abstract

    Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility and prognosis. SNPS were determined by restriction fragment length polymorphisms in patients and controls. AS patients exhibited a decreased frequency of the A allele at position -238 (10%) when compared with controls (18%), suggesting that this could be a protective factor for disease susceptibility. In addition, the -308 GA/AA genotypes were associated with later disease onset in AS patients. These results suggest that TNF gene promoter polymorphisms at positions -238 and -308 could have a small influence on AS susceptibility and prognosis.
    Original languageEnglish
    Title of host publicationContemporary Challenges in Autoimmunity
    PublisherWiley-Blackwell
    Pages581-588
    Volume1173
    DOIs
    Publication statusPublished - 2009
    Event6th International Congress on Autoimmunity - Oporto, Portugal
    Duration: 2008 Sept 102008 Sept 14

    Publication series

    Name
    Volume1173
    ISSN (Print)0077-8923

    Conference

    Conference6th International Congress on Autoimmunity
    Country/TerritoryPortugal
    CityOporto
    Period2008/09/102008/09/14

    Subject classification (UKÄ)

    • Biophysics

    Free keywords

    • susceptibility
    • ankylosing spondylitis
    • TNF promoter polymorphisms
    • prognosis

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