Ankylosing Spondylitis Susceptibility and Severity-Contribution of TNF Gene Promoter Polymorphisms at Positions-238 and-308

Elsa Sousa, Joana Caetano-Lopes, Patricia Pinto, Fernando Pimentel, José Teles, Helena Canhao, Ana Rodrigues, Catarina Resende, Ana Filipa Mourao, Celia Ribeiro, Teresa Laura Pinto, Carlos Miranda Rosa, Jose Alberto Pereira da Silva, Jaime Branco, Francisco Ventura, Mario Viana Queiroz, Joao Eurico Fonseca

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

19 Citations (SciVal)

Abstract

Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility and prognosis. SNPS were determined by restriction fragment length polymorphisms in patients and controls. AS patients exhibited a decreased frequency of the A allele at position -238 (10%) when compared with controls (18%), suggesting that this could be a protective factor for disease susceptibility. In addition, the -308 GA/AA genotypes were associated with later disease onset in AS patients. These results suggest that TNF gene promoter polymorphisms at positions -238 and -308 could have a small influence on AS susceptibility and prognosis.
Original languageEnglish
Title of host publicationContemporary Challenges in Autoimmunity
PublisherWiley-Blackwell
Pages581-588
Volume1173
DOIs
Publication statusPublished - 2009
Event6th International Congress on Autoimmunity - Oporto, Portugal
Duration: 2008 Sep 102008 Sep 14

Publication series

Name
Volume1173
ISSN (Print)0077-8923

Conference

Conference6th International Congress on Autoimmunity
Country/TerritoryPortugal
CityOporto
Period2008/09/102008/09/14

Subject classification (UKÄ)

  • Biophysics

Keywords

  • susceptibility
  • ankylosing spondylitis
  • TNF promoter polymorphisms
  • prognosis

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