Another piece of the p27Kip1 puzzle

Research output: Contribution to journalReview articlepeer-review


How extracellular signals communicate with the cell cycle is poorly understood. In this issue, two papers (Grimmler et al., 2007; Chu et al., 2007) address this problem by reporting phosphorylation of the cyclin-dependent kinase inhibitor p27Kip1 on a tyrosine residue by nonreceptor tyrosine kinases, which decreases p27 stability. This new mechanism could explain how cells enter the cell cycle from a quiescent state.

Original languageEnglish
Pages (from-to)241-244
Issue number2
Publication statusPublished - 2007 Jan 26
Externally publishedYes

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