Abstract
From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.
| Original language | English |
|---|---|
| Pages (from-to) | 619-622 |
| Journal | Natural Product Communications |
| Volume | 1 |
| Issue number | 8 |
| Publication status | Published - 2006 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
Subject classification (UKÄ)
- Organic Chemistry
Free keywords
- trypanosomiasis
- antitrypanosomal
- alkaloids
- Xymalos monospora
- monimiaceae
- sleeping sickness
