Antileishmanial metabolites from Trixis antimenorrhoea

Eliana Maldonado; Efrain Salamanca; Alberto Gimenez; Gloria Saavedra; Olov Sterner

doi:10.1016/j.phytol.2014.10.017

Antileishmanial metabolites from Trixis antimenorrhoea

Eliana Maldonado, Efrain Salamanca, Alberto Gimenez, Gloria Saavedra, Olov Sterner

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

Abstract

An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	281-286
Journal	Phytochemistry Letters
Volume	10
DOIs	https://doi.org/10.1016/j.phytol.2014.10.017
Publication status	Published - 2014

Subject classification (UKÄ)

Chemical Sciences

Free keywords

Trixis antimenorrhoea
Nortrixane
Trixanolide
Antileishmanial
activity
Structural elucidation

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10.1016/j.phytol.2014.10.017

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title = "Antileishmanial metabolites from Trixis antimenorrhoea",

abstract = "An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.",

keywords = "Trixis antimenorrhoea, Nortrixane, Trixanolide, Antileishmanial, activity, Structural elucidation",

author = "Eliana Maldonado and Efrain Salamanca and Alberto Gimenez and Gloria Saavedra and Olov Sterner",

year = "2014",

doi = "10.1016/j.phytol.2014.10.017",

language = "English",

volume = "10",

pages = "281--286",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier",

}

TY - JOUR

T1 - Antileishmanial metabolites from Trixis antimenorrhoea

AU - Maldonado, Eliana

AU - Salamanca, Efrain

AU - Gimenez, Alberto

AU - Saavedra, Gloria

AU - Sterner, Olov

PY - 2014

Y1 - 2014

N2 - An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

AB - An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

KW - Trixis antimenorrhoea

KW - Nortrixane

KW - Trixanolide

KW - Antileishmanial

KW - activity

KW - Structural elucidation

U2 - 10.1016/j.phytol.2014.10.017

DO - 10.1016/j.phytol.2014.10.017

M3 - Article

SN - 1874-3900

VL - 10

SP - 281

EP - 286

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Antileishmanial metabolites from Trixis antimenorrhoea

Abstract

Subject classification (UKÄ)

Free keywords

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