Antileishmanial metabolites from Trixis antimenorrhoea

Eliana Maldonado, Efrain Salamanca, Alberto Gimenez, Gloria Saavedra, Olov Sterner

Research output: Contribution to journalArticlepeer-review

7 Citations (SciVal)

Abstract

An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)281-286
JournalPhytochemistry Letters
Volume10
DOIs
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Chemical Sciences

Keywords

  • Trixis antimenorrhoea
  • Nortrixane
  • Trixanolide
  • Antileishmanial
  • activity
  • Structural elucidation

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