Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

Ivan Limachi; Claudia Condo; Camila Palma; Nelida Nina; Efrain Salamanca; Juan C. Ticona; Enrique Udaeta; Ninoska Flores; Alcides Serato; Natalio Marupa; Benigno Chao; Gladys Ibaguari; Constantino Nay; Soffie Manner; Olov Sterner; Alberto Giménez

doi:10.1177/1934578X1901400115

Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

Ivan Limachi, Claudia Condo, Camila Palma, Nelida Nina, Efrain Salamanca, Juan C. Ticona, Enrique Udaeta, Ninoska Flores, Alcides Serato, Natalio Marupa, Benigno Chao, Gladys Ibaguari, Constantino Nay, Soffie Manner, Olov Sterner, Alberto Giménez

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

Abstract

A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.

Original language	English
Pages (from-to)	55-58
Number of pages	4
Journal	Natural Product Communications
Volume	14
Issue number	1
DOIs	https://doi.org/10.1177/1934578X1901400115
Publication status	Published - 2019

Subject classification (UKÄ)

Pharmaceutical Sciences
Microbiology

Free keywords

Bolivia
Cytotoxicity
Giardia lamblia
Hyptis brevipes
Leishmania spp
Plasmodium falciparum
Tacana
Trypanosoma cruzi

Access to Document

10.1177/1934578X1901400115Licence: Unspecified

1 Doctoral Thesis (compilation)

Antiparasitic metabolites from plants used in the Tacana Bolivian native tribe: Traditional medicine, an overview of natural products with medicinal interest.
Limachi, I., 2019 Dec 5, lund, Sweden: Centre for Analysis and Synthesis, Department of Chemistry, Lund University. 265 p.
Research output: Thesis › Doctoral Thesis (compilation)

Open Access
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Cite this

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title = "Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant",

abstract = "A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.",

keywords = "Bolivia, Cytotoxicity, Giardia lamblia, Hyptis brevipes, Leishmania spp, Plasmodium falciparum, Tacana, Trypanosoma cruzi",

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doi = "10.1177/1934578X1901400115",

language = "English",

volume = "14",

pages = "55--58",

journal = "Natural Product Communications",

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T1 - Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

AU - Limachi, Ivan

AU - Condo, Claudia

AU - Palma, Camila

AU - Nina, Nelida

AU - Salamanca, Efrain

AU - Ticona, Juan C.

AU - Udaeta, Enrique

AU - Flores, Ninoska

AU - Serato, Alcides

AU - Marupa, Natalio

AU - Chao, Benigno

AU - Ibaguari, Gladys

AU - Nay, Constantino

AU - Manner, Soffie

AU - Sterner, Olov

AU - Giménez, Alberto

PY - 2019

Y1 - 2019

N2 - A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.

AB - A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.

KW - Bolivia

KW - Cytotoxicity

KW - Giardia lamblia

KW - Hyptis brevipes

KW - Leishmania spp

KW - Plasmodium falciparum

KW - Tacana

KW - Trypanosoma cruzi

U2 - 10.1177/1934578X1901400115

DO - 10.1177/1934578X1901400115

M3 - Article

AN - SCOPUS:85063748149

SN - 1934-578X

VL - 14

SP - 55

EP - 58

JO - Natural Product Communications

JF - Natural Product Communications

IS - 1

ER -

Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

Abstract

Subject classification (UKÄ)

Free keywords

Access to Document

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Research output

Antiparasitic metabolites from plants used in the Tacana Bolivian native tribe: Traditional medicine, an overview of natural products with medicinal interest.

Cite this