Antiproliferative effects of curcuphenol, a sesquiterpene phenol.

Gloria Rodrigo, Geovanna Almanza, Yajun Cheng, Jiangnan Peng, Mark Hamann, Rui-Dong Duan, Björn Åkesson

Research output: Contribution to journalArticlepeer-review

Abstract

Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116microg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.
Original languageEnglish
Pages (from-to)762-766
JournalFitoterapia
Volume81
Issue number7
DOIs
Publication statusPublished - 2010

Subject classification (UKÄ)

  • Other Clinical Medicine

Free keywords

  • Cell proliferation
  • Curcuphenol
  • Apoptosis
  • Caspase

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