Abstract
Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116microg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.
Original language | English |
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Pages (from-to) | 762-766 |
Journal | Fitoterapia |
Volume | 81 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2010 |
Subject classification (UKÄ)
- Other Clinical Medicine
Free keywords
- Cell proliferation
- Curcuphenol
- Apoptosis
- Caspase