Antiproliferative effects of peracetylated naphthoxylosides.

Ulrika Aili; Mårten Jacobsson; Richard Johnsson; Katrin Mani; Ulf Ellervik

doi:10.1016/j.bmcl.2009.01.065

Antiproliferative effects of peracetylated naphthoxylosides.

Ulrika Aili, Mårten Jacobsson, Richard Johnsson, Katrin Mani, Ulf Ellervik

Research output: Contribution to journal › Article › peer-review

6 Citations (SciVal)

Abstract

The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.

Original language	English
Pages (from-to)	1763-1766
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	19
DOIs	https://doi.org/10.1016/j.bmcl.2009.01.065
Publication status	Published - 2009

Subject classification (UKÄ)

Medicinal Chemistry

Access to Document

10.1016/j.bmcl.2009.01.065

http://www.ncbi.nlm.nih.gov/pubmed/19217282?dopt=Abstract

6 Citations
1 Doctoral Thesis (compilation)

Tumor Selective Antiproliferative Naphthoxylosides
Aili, U., 2013, Glycobiology, Dept of Experimental Medical Science. 94 p.
Research output: Thesis › Doctoral Thesis (compilation)

Cite this

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title = "Antiproliferative effects of peracetylated naphthoxylosides.",

abstract = "The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.",

author = "Ulrika Aili and M{\aa}rten Jacobsson and Richard Johnsson and Katrin Mani and Ulf Ellervik",

year = "2009",

doi = "10.1016/j.bmcl.2009.01.065",

language = "English",

volume = "19",

pages = "1763--1766",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

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T1 - Antiproliferative effects of peracetylated naphthoxylosides.

AU - Aili, Ulrika

AU - Jacobsson, Mårten

AU - Johnsson, Richard

AU - Mani, Katrin

AU - Ellervik, Ulf

PY - 2009

Y1 - 2009

N2 - The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.

AB - The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.

U2 - 10.1016/j.bmcl.2009.01.065

DO - 10.1016/j.bmcl.2009.01.065

M3 - Article

VL - 19

SP - 1763

EP - 1766

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

ER -

Antiproliferative effects of peracetylated naphthoxylosides.

Abstract

Subject classification (UKÄ)

Access to Document

Fingerprint

Research output

Tumor Selective Antiproliferative Naphthoxylosides

Cite this