Applications of protein-based capacitive biosensors for the detection of heavy-metal ions

Alessia Mortari, N.L. Brown, C. Geczy, H.G.L. Coster, S.M. Valenzuela, D. Martin, Elisabeth Csöregi

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

Three different methods of using protein-based capacitive biosensors for the detection of heavy-metal ions are presented. The metal-binding proteins SmtA, S100A12, MerP and four modified MerPs were immobilised as the bio-recognition element on self-assembled monolayer-modified gold electrodes. Capacitance was measured using potential square step or electrical impedance spectroscopy. The protein-metal interaction generated changes in capacitance mainly due to a protein conformational change.
Original languageEnglish
Title of host publication2006 International Conference on Nanoscience and Nanotechnology (IEEE Cat. No.06EX1411)
PublisherIEEE - Institute of Electrical and Electronics Engineers Inc.
Pages304-307
Number of pages4
ISBN (Print)1-4244-0452-5
DOIs
Publication statusPublished - 2006
Event2006 International Conference on Nanoscience and Nanotechnology - Brisbane, Qld., Australia
Duration: 2006 Jul 32006 Jul 7

Conference

Conference2006 International Conference on Nanoscience and Nanotechnology
Country/TerritoryAustralia
CityBrisbane, Qld.
Period2006/07/032006/07/07

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)

Subject classification (UKÄ)

  • Analytical Chemistry

Free keywords

  • electrical impedance spectroscopy
  • self-assembled monolayer-modified gold electrodes
  • bio-recognition element
  • metal-binding proteins
  • protein-based capacitive biosensors
  • heavy-metal ion detection
  • electrochemical capacitance
  • environmental application
  • biomedical application

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