Artery blood pressure oscillation after active standing up: an indicator of sympathetic function in diabetic patients

A Lindqvist, Ole Torffvit, Ralf Rittner, Carl-David Agardh, Olle Pahlm

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Dynamic artery blood pressure (Finapres) response to active standing up, normally consisting of initial rise, fall and recovery above the baseline (overshoot), was compared with the early steady-state artery blood pressure level to measure sympathetic vasomotor function in healthy subjects (n = 23, age 35 +/- 9 years; mean +/-SD) and in type I diabetic patients without autonomic neuropathy (AN) (group 1: n = 18, 38 +/- 13 years), with AN but no cardiovascular drugs (group 2a: n = 7, 44 +/- 11 years) and with both AN and cardiovascular drugs (group 2b: n = 10, 47 +/- 7 years). Systolic and diastolic overshoot were similar in the control (15 +/- 13/15 +/- 11 mmHg) and group 1 subjects. Systolic overshoot disappeared in 57% of patients in group 2a (-1 +/- 9 mmHg; P < 0.03), whereas artery blood pressure still overshot in diastole (8 +/- 7 mmHg; NS). Systolic overshoot disappeared in all patients in group 2b (-22 +/- 22 mmHg; P < 0.0006) and diastolic overshoot disappeared in 60% of these patients (-6 +/- 16 mmHg; P = 0.0006). Systolic early steady-state level was not lower in group 2a than in group 1 (NS), but it was impaired in group 2b (P < 0.006), in which six diabetic patients had a pathological response beyond the age-related reference values. There was a strong association between the overshoot and steady-state levels (P for chi 2 < 0.001, n = 58). Overshoot of the control subjects and patients in group 2b correlated to their respective steady-state blood pressure levels (r > or = 0.76; P < or = 0.001). In conclusion, baroreceptor reflex-dependent overshoot of the artery blood pressure after active standing up diminishes with the development of AN and it is associated with the early steady-state level of the artery blood pressure.
Original languageEnglish
Pages (from-to)159-169
JournalClinical Physiology
Issue number2
Publication statusPublished - 1997

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510), Department of Clinical Physiology (Lund) (013013000), Division of Occupational and Environmental Medicine (013078001), Medicine (Lund) (013230025)

Subject classification (UKÄ)

  • Respiratory Medicine and Allergy
  • Endocrinology and Diabetes
  • Environmental Health and Occupational Health
  • Other Clinical Medicine
  • Cardiac and Cardiovascular Systems


  • artery blood pressure
  • asympathicotonic response
  • autonomic neuropathy
  • diabetes mellitus
  • baroreflex
  • blood pressure overshoot
  • Finapres
  • orthostatic test


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