Assessment of fracture risk

JA Kanis, F Borgstrom, C De Laet, H Johansson, Olof Johnell, B Jonsson, A Oden, N Zethraeus, B Pfleger, N Khaltaev

Research output: Contribution to journalReview articlepeer-review

906 Citations (SciVal)


The diagnosis of osteoporosis is based on the measurement of bone mineral density (BMD). There are a number of clinical risk factors that provide information on fracture risk over and above that given by BMD. The assessment of fracture risk thus needs to be distinguished from diagnosis to take account of the independent value of the clinical risk factors. These include age, a prior fragility fracture, a parental history of hip fracture, smoking, use of systemic corticosteroids, excess alcohol intake and rheumatoid arthritis. The independent contribution of these risk factors can be integrated by the calculation of fracture probability with or without the use of BMD. Treatment can then be offered to those identified to have a fracture probability greater than an intervention threshold.
Original languageEnglish
Pages (from-to)581-589
JournalOsteoporosis International
Issue number6
Publication statusPublished - 2005

Subject classification (UKÄ)

  • Orthopedics


  • case-finding
  • threshold
  • intervention
  • clinical risk factors
  • fracture probability


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