Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

Jason L. Vassy, Peter Shrader, Anna Jonsson, Caroline S. Fox, Valeriya Lyssenko, Bo Isomaa, Leif Groop, James B. Meigs, Paul Franks

Research output: Contribution to journalArticlepeer-review

17 Citations (SciVal)

Abstract

Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend) = 0.03). The trend was similar among Framingham Offspring but was not statistically significant (p = 0.07). The meta-analyzed p value for trend from the two studies was 0.005. Conclusions: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)E76-E79
JournalDiabetes Research and Clinical Practice
Volume93
Issue number2
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Endocrinology and Diabetes

Keywords

  • Type 2 diabetes mellitus
  • Genetic risk score
  • Family history

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