Association between Subcortical Lesions and Behavioral and Psychological Symptoms in Patients with Alzheimer's Disease.

Sebastian Palmqvist, Agmall Sarwari, Carina Wattmo, Lena Bronge, Yi Zhang, Lars Olof Wahlund, Katarina Nägga

Research output: Contribution to journalArticlepeer-review

31 Citations (SciVal)
212 Downloads (Pure)

Abstract

Background/Aims: The most devastating features of Alz-heimer's disease (AD) are often the behavioral and psychological symptoms in dementia (BPSD). There is controversy as to whether subcortical lesions contribute to BPSD. The aim of this study was to examine the relationship between BPSD and subcortical lesions (white-matter lesions and lacunes) in AD.

Methods: CT or MRI from 259 patients with mild-to-moderate AD were assessed with the Age-Related White Matter Changes scale. Linear measures of global and temporal atrophy and Mini-Mental State Examination scores were used to adjust for AD pathology and disease severity in logistic regression models with the BPSD items delusions, hallucinations, agitation, depression, anxiety, apathy and irritability.

Results: Lacunes in the left basal ganglia were asso-ciated with delusions (OR 2.57, 95% CI 1.21-5.48) and hallucinations (OR 3.33, 95% CI 1.38-8.01) and lacunes in the right basal ganglia were associated with depression (OR 2.13, 95% CI 1.01-4.51).

Conclusion: Lacunes in the basal ganglia resulted in a 2- to 3-fold increased risk of delusions, hallucinations and depression, when adjusting for cognition and atrophy. This suggests that basal ganglia lesions can contribute to BPSD in patients with AD, independently of the AD process.
Original languageEnglish
Pages (from-to)417-423
JournalDementia and Geriatric Cognitive Disorders
Volume32
Issue number6
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Neurology

Fingerprint

Dive into the research topics of 'Association between Subcortical Lesions and Behavioral and Psychological Symptoms in Patients with Alzheimer's Disease.'. Together they form a unique fingerprint.

Cite this