Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.

Irina Strazhesko; Olga Tkacheva; Sergey Boytsov; Dariga Akasheva; Ekaterina Dudinskaya; Vladimir Vygodin; Dmitry Skvortsov; Peter Nilsson

doi:10.1371/journal.pone.0136676

Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.

Irina Strazhesko, Olga Tkacheva, Sergey Boytsov, Dariga Akasheva, Ekaterina Dudinskaya, Vladimir Vygodin, Dmitry Skvortsov, Peter Nilsson

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Abstract

Chronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory and oxidative stress. We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femoral pulse wave velocity (c-f PWV).

Original language	English
Article number	e0136676
Journal	PLoS ONE
Volume	10
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0136676
Publication status	Published - 2015

Subject classification (UKÄ)

Cardiology and Cardiovascular Disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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http://www.ncbi.nlm.nih.gov/pubmed/26308091?dopt=Abstract

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title = "Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.",

abstract = "Chronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory and oxidative stress. We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femoral pulse wave velocity (c-f PWV).",

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AU - Strazhesko, Irina

AU - Tkacheva, Olga

AU - Boytsov, Sergey

AU - Akasheva, Dariga

AU - Dudinskaya, Ekaterina

AU - Vygodin, Vladimir

AU - Skvortsov, Dmitry

AU - Nilsson, Peter

PY - 2015

Y1 - 2015

N2 - Chronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory and oxidative stress. We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femoral pulse wave velocity (c-f PWV).

AB - Chronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory and oxidative stress. We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femoral pulse wave velocity (c-f PWV).

U2 - 10.1371/journal.pone.0136676

DO - 10.1371/journal.pone.0136676

M3 - Article

C2 - 26308091

SN - 1932-6203

VL - 10

JO - PLoS ONE

JF - PLoS ONE

IS - 8

M1 - e0136676

ER -

Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.

Abstract

Subject classification (UKÄ)

UN SDGs

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