Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Gustav Smith; Kevin Luk; Christina-Alexandra Schulz; James C Engert; Ron Do; George Hindy; Gull Rukh; Line Dufresne; Peter Almgren; David S Owens; Tamara B Harris; Gina M Peloso; Kathleen F Kerr; Quenna Wong; Albert V Smith; Matthew J Budoff; Jerome I Rotter; L Adrienne Cupples; Stephen Rich; Sekar Kathiresan; Marju Orho-Melander; Vilmundur Gudnason; Christopher J O'Donnell; Wendy S Post; George Thanassoulis

doi:10.1001/jama.2014.13959

Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Gustav Smith, Kevin Luk, Christina-Alexandra Schulz, James C Engert, Ron Do, George Hindy, Gull Rukh, Line Dufresne, Peter Almgren, David S Owens, Tamara B Harris, Gina M Peloso, Kathleen F Kerr, Quenna Wong, Albert V Smith, Matthew J Budoff, Jerome I Rotter, L Adrienne Cupples, Stephen Rich, Sekar KathiresanMarju Orho-Melander, Vilmundur Gudnason, Christopher J O'Donnell, Wendy S Post, George Thanassoulis

Research output: Contribution to journal › Article › peer-review

Abstract

Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

Original language	English
Pages (from-to)	1764-1771
Journal	JAMA: The Journal of the American Medical Association
Volume	312
Issue number	17
DOIs	https://doi.org/10.1001/jama.2014.13959
Publication status	Published - 2014

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1001/jama.2014.13959

http://www.ncbi.nlm.nih.gov/pubmed/25344734?dopt=Abstract

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Smith, G., Luk, K., Schulz, C.-A., Engert, J. C., Do, R., Hindy, G., Rukh, G., Dufresne, L., Almgren, P., Owens, D. S., Harris, T. B., Peloso, G. M., Kerr, K. F., Wong, Q., Smith, A. V., Budoff, M. J., Rotter, J. I., Cupples, L. A., Rich, S., ... Thanassoulis, G. (2014). Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis. JAMA: The Journal of the American Medical Association, 312(17), 1764-1771. https://doi.org/10.1001/jama.2014.13959

@article{1babbb4869c44bceb4f24ca2ffa8fc4e,

title = "Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.",

abstract = "Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.",

author = "Gustav Smith and Kevin Luk and Christina-Alexandra Schulz and Engert, {James C} and Ron Do and George Hindy and Gull Rukh and Line Dufresne and Peter Almgren and Owens, {David S} and Harris, {Tamara B} and Peloso, {Gina M} and Kerr, {Kathleen F} and Quenna Wong and Smith, {Albert V} and Budoff, {Matthew J} and Rotter, {Jerome I} and Cupples, {L Adrienne} and Stephen Rich and Sekar Kathiresan and Marju Orho-Melander and Vilmundur Gudnason and O'Donnell, {Christopher J} and Post, {Wendy S} and George Thanassoulis",

year = "2014",

doi = "10.1001/jama.2014.13959",

language = "English",

volume = "312",

pages = "1764--1771",

journal = "JAMA: The Journal of the American Medical Association",

issn = "1538-3598",

publisher = "American Medical Association",

number = "17",

}

Smith, G, Luk, K, Schulz, C-A, Engert, JC, Do, R, Hindy, G, Rukh, G, Dufresne, L, Almgren, P, Owens, DS, Harris, TB, Peloso, GM, Kerr, KF, Wong, Q, Smith, AV, Budoff, MJ, Rotter, JI, Cupples, LA, Rich, S, Kathiresan, S, Orho-Melander, M, Gudnason, V, O'Donnell, CJ, Post, WS & Thanassoulis, G 2014, 'Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.', JAMA: The Journal of the American Medical Association, vol. 312, no. 17, pp. 1764-1771. https://doi.org/10.1001/jama.2014.13959

TY - JOUR

T1 - Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

AU - Smith, Gustav

AU - Luk, Kevin

AU - Schulz, Christina-Alexandra

AU - Engert, James C

AU - Do, Ron

AU - Hindy, George

AU - Rukh, Gull

AU - Dufresne, Line

AU - Almgren, Peter

AU - Owens, David S

AU - Harris, Tamara B

AU - Peloso, Gina M

AU - Kerr, Kathleen F

AU - Wong, Quenna

AU - Smith, Albert V

AU - Budoff, Matthew J

AU - Rotter, Jerome I

AU - Cupples, L Adrienne

AU - Rich, Stephen

AU - Kathiresan, Sekar

AU - Orho-Melander, Marju

AU - Gudnason, Vilmundur

AU - O'Donnell, Christopher J

AU - Post, Wendy S

AU - Thanassoulis, George

PY - 2014

Y1 - 2014

N2 - Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

AB - Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.

U2 - 10.1001/jama.2014.13959

DO - 10.1001/jama.2014.13959

M3 - Article

C2 - 25344734

SN - 1538-3598

VL - 312

SP - 1764

EP - 1771

JO - JAMA: The Journal of the American Medical Association

JF - JAMA: The Journal of the American Medical Association

IS - 17

ER -

Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Abstract

Subject classification (UKÄ)

UN SDGs

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