Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

KM Smits; S Benhamou; S Garte; MP Weijenberg; Y Alamanos; C Ambrosone; H Autrup; JL Autrup; H Baranova; L Bathum; P Boffetta; C Bouchardy; J Brockmoller; D Butkiewicz; I Cascorbi; ML Clapper; C Coutelle; AK Daly; G Muzi; V Dolzan; TG Duzhak; K Farker; K Golka; A Haugen; DW Hein; A Hildesheim; A Hirvonen; LL Hsieh; M Ingelman-Sundberg; I Kalina; D Kang; T Katoh; M Kihara; M Ono-Kihara; H Kim; C Kiyohara; P Kremers; P Lazarus; L Le Marchand; MC Lechner; S London; JJ Manni; CM Maugard; GJ Morgan; S Morita; V Nazar-Stewart; VN Kristensen; Y Oda; FF Parl; WHM Peters; A Rannug; T Rebbeck; LFR Pinto; A Risch; M Romkes; J Salagovic; B Schoket; Janeric Seidegård; PG Shields; E Sim; D Sinnett; RC Strange; I Stucker; H Sugimura; J To-Figueras; P Vineis; MC Yu; W Zheng; P Pedotti; E Taioli

doi:10.1002/ijc.20114

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

KM Smits, S Benhamou, S Garte, MP Weijenberg, Y Alamanos, C Ambrosone, H Autrup, JL Autrup, H Baranova, L Bathum, P Boffetta, C Bouchardy, J Brockmoller, D Butkiewicz, I Cascorbi, ML Clapper, C Coutelle, AK Daly, G Muzi, V DolzanTG Duzhak, K Farker, K Golka, A Haugen, DW Hein, A Hildesheim, A Hirvonen, LL Hsieh, M Ingelman-Sundberg, I Kalina, D Kang, T Katoh, M Kihara, M Ono-Kihara, H Kim, C Kiyohara, P Kremers, P Lazarus, L Le Marchand, MC Lechner, S London, JJ Manni, CM Maugard, GJ Morgan, S Morita, V Nazar-Stewart, VN Kristensen, Y Oda, FF Parl, WHM Peters, A Rannug, T Rebbeck, LFR Pinto, A Risch, M Romkes, J Salagovic, B Schoket, Janeric Seidegård, PG Shields, E Sim, D Sinnett, RC Strange, I Stucker, H Sugimura, J To-Figueras, P Vineis, MC Yu, W Zheng, P Pedotti, E Taioli

Section V

Research output: Contribution to journal › Article › peer-review

Abstract

Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYPIAI, GSTMI, GSTTI, NAT2 and GSTPI. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.

Original language	English
Pages (from-to)	266-270
Journal	International Journal of Cancer
Volume	110
Issue number	2
DOIs	https://doi.org/10.1002/ijc.20114
Publication status	Published - 2004

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

pooled analysis
molecular epidemiology
smoking

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.20114

Cite this

Smits, KM., Benhamou, S., Garte, S., Weijenberg, MP., Alamanos, Y., Ambrosone, C., Autrup, H., Autrup, JL., Baranova, H., Bathum, L., Boffetta, P., Bouchardy, C., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, ML., Coutelle, C., Daly, AK., Muzi, G., ... Taioli, E. (2004). Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. International Journal of Cancer, 110(2), 266-270. https://doi.org/10.1002/ijc.20114

@article{4727cd566f064e40b26f063f4619983e,

title = "Association of metabolic gene polymorphisms with tobacco consumption in healthy controls",

abstract = "Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYPIAI, GSTMI, GSTTI, NAT2 and GSTPI. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.",

keywords = "pooled analysis, molecular epidemiology, smoking",

author = "KM Smits and S Benhamou and S Garte and MP Weijenberg and Y Alamanos and C Ambrosone and H Autrup and JL Autrup and H Baranova and L Bathum and P Boffetta and C Bouchardy and J Brockmoller and D Butkiewicz and I Cascorbi and ML Clapper and C Coutelle and AK Daly and G Muzi and V Dolzan and TG Duzhak and K Farker and K Golka and A Haugen and DW Hein and A Hildesheim and A Hirvonen and LL Hsieh and M Ingelman-Sundberg and I Kalina and D Kang and T Katoh and M Kihara and M Ono-Kihara and H Kim and C Kiyohara and P Kremers and P Lazarus and {Le Marchand}, L and MC Lechner and S London and JJ Manni and CM Maugard and GJ Morgan and S Morita and V Nazar-Stewart and VN Kristensen and Y Oda and FF Parl and WHM Peters and A Rannug and T Rebbeck and LFR Pinto and A Risch and M Romkes and J Salagovic and B Schoket and Janeric Seideg{\aa}rd and PG Shields and E Sim and D Sinnett and RC Strange and I Stucker and H Sugimura and J To-Figueras and P Vineis and MC Yu and W Zheng and P Pedotti and E Taioli",

year = "2004",

doi = "10.1002/ijc.20114",

language = "English",

volume = "110",

pages = "266--270",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley & Sons Inc.",

number = "2",

}

Smits, KM, Benhamou, S, Garte, S, Weijenberg, MP, Alamanos, Y, Ambrosone, C, Autrup, H, Autrup, JL, Baranova, H, Bathum, L, Boffetta, P, Bouchardy, C, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, ML, Coutelle, C, Daly, AK, Muzi, G, Dolzan, V, Duzhak, TG, Farker, K, Golka, K, Haugen, A, Hein, DW, Hildesheim, A, Hirvonen, A, Hsieh, LL, Ingelman-Sundberg, M, Kalina, I, Kang, D, Katoh, T, Kihara, M, Ono-Kihara, M, Kim, H, Kiyohara, C, Kremers, P, Lazarus, P, Le Marchand, L, Lechner, MC, London, S, Manni, JJ, Maugard, CM, Morgan, GJ, Morita, S, Nazar-Stewart, V, Kristensen, VN, Oda, Y, Parl, FF, Peters, WHM, Rannug, A, Rebbeck, T, Pinto, LFR, Risch, A, Romkes, M, Salagovic, J, Schoket, B, Seidegård, J, Shields, PG, Sim, E, Sinnett, D, Strange, RC, Stucker, I, Sugimura, H, To-Figueras, J, Vineis, P, Yu, MC, Zheng, W, Pedotti, P & Taioli, E 2004, 'Association of metabolic gene polymorphisms with tobacco consumption in healthy controls', International Journal of Cancer, vol. 110, no. 2, pp. 266-270. https://doi.org/10.1002/ijc.20114

TY - JOUR

T1 - Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

AU - Smits, KM

AU - Benhamou, S

AU - Garte, S

AU - Weijenberg, MP

AU - Alamanos, Y

AU - Ambrosone, C

AU - Autrup, H

AU - Autrup, JL

AU - Baranova, H

AU - Bathum, L

AU - Boffetta, P

AU - Bouchardy, C

AU - Brockmoller, J

AU - Butkiewicz, D

AU - Cascorbi, I

AU - Clapper, ML

AU - Coutelle, C

AU - Daly, AK

AU - Muzi, G

AU - Dolzan, V

AU - Duzhak, TG

AU - Farker, K

AU - Golka, K

AU - Haugen, A

AU - Hein, DW

AU - Hildesheim, A

AU - Hirvonen, A

AU - Hsieh, LL

AU - Ingelman-Sundberg, M

AU - Kalina, I

AU - Kang, D

AU - Katoh, T

AU - Kihara, M

AU - Ono-Kihara, M

AU - Kim, H

AU - Kiyohara, C

AU - Kremers, P

AU - Lazarus, P

AU - Le Marchand, L

AU - Lechner, MC

AU - London, S

AU - Manni, JJ

AU - Maugard, CM

AU - Morgan, GJ

AU - Morita, S

AU - Nazar-Stewart, V

AU - Kristensen, VN

AU - Oda, Y

AU - Parl, FF

AU - Peters, WHM

AU - Rannug, A

AU - Rebbeck, T

AU - Pinto, LFR

AU - Risch, A

AU - Romkes, M

AU - Salagovic, J

AU - Schoket, B

AU - Seidegård, Janeric

AU - Shields, PG

AU - Sim, E

AU - Sinnett, D

AU - Strange, RC

AU - Stucker, I

AU - Sugimura, H

AU - To-Figueras, J

AU - Vineis, P

AU - Yu, MC

AU - Zheng, W

AU - Pedotti, P

AU - Taioli, E

PY - 2004

Y1 - 2004

N2 - Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYPIAI, GSTMI, GSTTI, NAT2 and GSTPI. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.

AB - Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYPIAI, GSTMI, GSTTI, NAT2 and GSTPI. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.

KW - pooled analysis

KW - molecular epidemiology

KW - smoking

U2 - 10.1002/ijc.20114

DO - 10.1002/ijc.20114

M3 - Article

SN - 0020-7136

VL - 110

SP - 266

EP - 270

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 2

ER -

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

Fingerprint

Cite this