Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.

L A Valentino, S W Pipe, P W Collins, V S Blanchette, Erik Berntorp, K Fischer, B M Ewenstein, M Oh, G Spotts

Research output: Contribution to journalArticlepeer-review

47 Citations (SciVal)

Abstract

We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.
Original languageEnglish
Pages (from-to)514-20
JournalHaemophilia
Volume22
Issue number4
Early online date2016 Mar 1
DOIs
Publication statusPublished - 2016

Subject classification (UKÄ)

  • Hematology

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