Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.

L A Valentino; S W Pipe; P W Collins; V S Blanchette; Erik Berntorp; K Fischer; B M Ewenstein; M Oh; G Spotts

doi:10.1111/hae.12905

Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.

L A Valentino, S W Pipe, P W Collins, V S Blanchette, Erik Berntorp, K Fischer, B M Ewenstein, M Oh, G Spotts

Clinical Coagulation, Malmö

Research output: Contribution to journal › Article › peer-review

47 Citations (SciVal)

Abstract

We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.

Original language	English
Pages (from-to)	514-20
Journal	Haemophilia
Volume	22
Issue number	4
Early online date	2016 Mar 1
DOIs	https://doi.org/10.1111/hae.12905
Publication status	Published - 2016

Subject classification (UKÄ)

Hematology

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10.1111/hae.12905

http://www.ncbi.nlm.nih.gov/pubmed/26930418?dopt=Abstract

Cite this

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title = "Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.",

abstract = "We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.",

author = "Valentino, {L A} and Pipe, {S W} and Collins, {P W} and Blanchette, {V S} and Erik Berntorp and K Fischer and Ewenstein, {B M} and M Oh and G Spotts",

year = "2016",

doi = "10.1111/hae.12905",

language = "English",

volume = "22",

pages = "514--20",

journal = "Haemophilia",

issn = "1351-8216",

publisher = "Blackwell",

number = "4",

}

Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis. / Valentino, L A; Pipe, S W; Collins, P W; Blanchette, V S; Berntorp, Erik; Fischer, K; Ewenstein, B M; Oh, M; Spotts, G.

In: Haemophilia, Vol. 22, No. 4, 2016, p. 514-20.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.

AU - Valentino, L A

AU - Pipe, S W

AU - Collins, P W

AU - Blanchette, V S

AU - Berntorp, Erik

AU - Fischer, K

AU - Ewenstein, B M

AU - Oh, M

AU - Spotts, G

PY - 2016

Y1 - 2016

N2 - We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.

AB - We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.

U2 - 10.1111/hae.12905

DO - 10.1111/hae.12905

M3 - Article

C2 - 26930418

VL - 22

SP - 514

EP - 520

JO - Haemophilia

JF - Haemophilia

SN - 1351-8216

IS - 4

ER -

Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.

Abstract

Subject classification (UKÄ)

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