Association of Ultra-Processed Food Intake with Cardiovascular And Respiratory Disease Multimorbidity: A Prospective Cohort Study

Huiping Li, Shu Li, Hongxi Yang, Yuan Zhang, Yue Ma, Yabing Hou, Xinyu Zhang, Li Sun, Yan Borné, Yaogang Wang

Research output: Contribution to journalArticlepeer-review

Abstract

SCOPE: Evidence suggests a positive association between ultra-processed food (UPF) consumption and the incidence of cardiovascular disease (CVD). We aimed to investigate associations between UPF intake and respiratory disease, CVD, and their multimorbidity in a large prospective cohort.

METHODS AND RESULTS: Within the UK Biobank, participants who were free from respiratory disease or CVD at baseline and completed at least two times 24-h dietary records were included in this study. After adjusting for socioeconomic status and lifestyle factors, the hazard ratios (95% confidence interval) for each ten percent increase in UPF were 1.06 (1.04, 1.09) for CVD, 1.04 (1.02, 1.06) for respiratory disease, 1.15 (1.08, 1.22) for CVD mortality, and 1.06 (1.01, 1.12) for their multimorbidity, respectively. In addition, replacing 20% of UPF weight in diet with an equivalent proportion of unprocessed or minimally processed foods was estimated to be associated with 11% lower risk of CVD, 7% lower risk of respiratory disease, 25% lower risk of CVD mortality and 11% lower risk of CVD and respiratory disease multimorbidity.

CONCLUSION: In this prospective cohort study, higher consumption of UPF was associated with higher risks of CVD and respiratory disease multimorbidity. Further longitudinal studies are needed to confirm our findings. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalMolecular Nutrition & Food Research
Volume67
Issue number11
Early online date2023 Mar 17
DOIs
Publication statusPublished - 2023

Subject classification (UKÄ)

  • Nutrition and Dietetics
  • Cardiac and Cardiovascular Systems

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