Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Anki Knutsson; Harry Björkbacka; Pontus Dunér; Gunnar Engström; Christoph J. Binder; Anna Hultgårdh Nilsson; Jan Nilsson

doi:10.1016/j.jacbts.2019.07.002

Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Anki Knutsson, Harry Björkbacka, Pontus Dunér, Gunnar Engström, Christoph J. Binder, Anna Hultgårdh Nilsson, Jan Nilsson

Medical University of Vienna

Research output: Contribution to journal › Article › peer-review

Abstract

Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe^−/− mice suggesting a protective role for IL-5 in plaque development.

Original language	English
Pages (from-to)	891-902
Number of pages	12
Journal	JACC: Basic to Translational Science
Volume	4
Issue number	8
DOIs	https://doi.org/10.1016/j.jacbts.2019.07.002
Publication status	Published - 2019

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems

Keywords

atherosclerosis
interleukin 5
myocardial infarction
stroke

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10.1016/j.jacbts.2019.07.002

Cite this

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title = "Associations of Interleukin-5 With Plaque Development and Cardiovascular Events",

abstract = "Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malm{\"o} Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development.",

keywords = "atherosclerosis, interleukin 5, myocardial infarction, stroke",

author = "Anki Knutsson and Harry Bj{\"o}rkbacka and Pontus Dun{\'e}r and Gunnar Engstr{\"o}m and Binder, {Christoph J.} and Nilsson, {Anna Hultg{\aa}rdh} and Jan Nilsson",

year = "2019",

doi = "10.1016/j.jacbts.2019.07.002",

language = "English",

volume = "4",

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journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

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T1 - Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

AU - Knutsson, Anki

AU - Björkbacka, Harry

AU - Dunér, Pontus

AU - Engström, Gunnar

AU - Binder, Christoph J.

AU - Nilsson, Anna Hultgårdh

AU - Nilsson, Jan

PY - 2019

Y1 - 2019

N2 - Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development.

AB - Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development.

KW - atherosclerosis

KW - interleukin 5

KW - myocardial infarction

KW - stroke

U2 - 10.1016/j.jacbts.2019.07.002

DO - 10.1016/j.jacbts.2019.07.002

M3 - Article

C2 - 31909299

AN - SCOPUS:85076709493

VL - 4

SP - 891

EP - 902

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

SN - 2452-302X

IS - 8

ER -

Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Abstract

Subject classification (UKÄ)

Keywords

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