Abstract
Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development.
Original language | English |
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Pages (from-to) | 891-902 |
Number of pages | 12 |
Journal | JACC: Basic to Translational Science |
Volume | 4 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2019 |
Subject classification (UKÄ)
- Cardiology and Cardiovascular Disease
Free keywords
- atherosclerosis
- interleukin 5
- myocardial infarction
- stroke