Asymmetric ring-opening of epoxides catalyzed by metal–salen complexes

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The asymmetric ring-opening of epoxides is an important reaction in organic synthesis, since it allows for the enantioselective installation of two vicinal functional groups with specific stereochemistry within one step from a highly available starting material. An effective class of catalysts for the asymmetric ring-opening of epoxides is metal–salen complexes. This review summarizes the development of metal–salen catalyzed enantioselective desymmetrization of meso-epoxides and kinetic resolution of epoxides with various nucleophiles, including the design and application of both homogeneous- and heterogeneous epoxide-opening catalysts as well as multi-metallic covalent and supramolecular catalytic systems.

Original languageEnglish
Article number705
Issue number6
Publication statusPublished - 2020

Subject classification (UKÄ)

  • Biocatalysis and Enzyme Technology

Free keywords

  • Asymmetric catalysis
  • Epoxide
  • Kinetic resolution
  • Ring-opening
  • Salen complexes


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