Attovial-based antibody nanoarrays.

Peter Ellmark, Sara Ghatnekar-Nilsson, André Meister, Harry Heinzelmann, Lars Montelius, Christer Wingren, Carl Borrebaeck

Research output: Contribution to journalArticlepeer-review

10 Citations (SciVal)

Abstract

Antibody array-based technology is a powerful emerging tool in proteomics, but to enable global proteome analysis, antibody array layouts with even higher density has to be developed. To this end, we have further developed the first generation of a nanoarray platform, based on attoliter sized vials, attovials, which we have characterized and used for the detection of complement factor C1q in human serum samples. Finally, we demonstrated proof-of-concept for individual functionalisation of the attovials with a recombinant antibody.
Original languageEnglish
Pages (from-to)5406-5413
JournalProteomics
Volume9
Issue number24
DOIs
Publication statusPublished - 2009

Subject classification (UKÄ)

  • Immunology in the medical area
  • Condensed Matter Physics

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