TY - JOUR
T1 - Automatic Measurements of Diameter, Distension and Intima Media Thickness of the Aorta in Premature Rabbit Pups Using B-Mode Images.
AU - Erlöv, Tobias
AU - Segstedt, Simon
AU - Milton, Patrik
AU - Sveinsdottir, Snjolaug
AU - Jansson, Tomas
AU - Persson, Hans W
AU - Ley, David
AU - Cinthio, Magnus
N1 - The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Paediatrics (Lund) (013002000), Department of Electrical Measurements (011022000)
PY - 2014
Y1 - 2014
N2 - To improve cardiovascular research, there is a growing need for arterial characterization in small animals. We developed a method, ARTIC (arterial characterization) for measuring lumen diameter, distension and intima media thickness (IMT). In this study ARTIC was used to automatically characterize the aorta of premature rabbit pups. Automatic measurements were compared with manual measurements, both performed by three observers. Diameter was 769 ± 140 μm (manual) and 766 ± 142 μm (automatic), distension was 35 ± 15 μm (manual) and 40 ± 12 μm (automatic) and IMT was 84 ± 11 μm (manual) and 88 ± 8 μm (automatic) (mean ± standard deviation). The variation in the measured diameter, distension and IMT ranged from 1.1% to 26.0% (manual) and from 1.0% to 9.0% (automatic). The intra-class correlation coefficient ranged from 33.0% to 99.3% (manual) and from 76.9% to 99.6% (automatic). The evaluation revealed that it is feasible to use ARTIC on B-mode images of arteries with small dimensions, which makes it a useful tool for arterial characterization in small animals.
AB - To improve cardiovascular research, there is a growing need for arterial characterization in small animals. We developed a method, ARTIC (arterial characterization) for measuring lumen diameter, distension and intima media thickness (IMT). In this study ARTIC was used to automatically characterize the aorta of premature rabbit pups. Automatic measurements were compared with manual measurements, both performed by three observers. Diameter was 769 ± 140 μm (manual) and 766 ± 142 μm (automatic), distension was 35 ± 15 μm (manual) and 40 ± 12 μm (automatic) and IMT was 84 ± 11 μm (manual) and 88 ± 8 μm (automatic) (mean ± standard deviation). The variation in the measured diameter, distension and IMT ranged from 1.1% to 26.0% (manual) and from 1.0% to 9.0% (automatic). The intra-class correlation coefficient ranged from 33.0% to 99.3% (manual) and from 76.9% to 99.6% (automatic). The evaluation revealed that it is feasible to use ARTIC on B-mode images of arteries with small dimensions, which makes it a useful tool for arterial characterization in small animals.
U2 - 10.1016/j.ultrasmedbio.2013.09.017
DO - 10.1016/j.ultrasmedbio.2013.09.017
M3 - Article
C2 - 24268455
SN - 0301-5629
VL - 40
SP - 371
EP - 377
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 2
ER -