Automation of Modeling and Calibration of Integrated Preparative Protein Chromatography Systems

Simon Tallvod; Niklas Andersson; Bernt Nilsson

doi:10.3390/pr10050945

Automation of Modeling and Calibration of Integrated Preparative Protein Chromatography Systems

Simon Tallvod, Niklas Andersson, Bernt Nilsson

Division of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

With the increasing global demand for precise and efficient pharmaceuticals and the biopharma industry moving towards Industry 4.0, the need for advanced process integration, automation, and modeling has increased as well. In this work, a method for automatic modeling and calibration of an integrated preparative chromatographic system for pharmaceutical development and production is presented. Based on a user-defined system description, a system model was automatically generated and then calibrated using a sequence of experiments. The system description and model was implemented in the Python-based preparative chromatography control software Orbit.

Original language	English
Article number	945
Journal	Processes
Volume	10
Issue number	5
DOIs	https://doi.org/10.3390/pr10050945
Publication status	Published - 2022

Subject classification (UKÄ)

Chemical Engineering
Computer and Information Sciences

Free keywords

chromatography modeling
digital twin
integrated continuous processes
model calibration
preparative chromatography
process automation

Access to Document

10.3390/pr10050945

1 Article
1 Doctoral Thesis (compilation)

Automatic procedure for modelling, calibration, and optimization of a three-component chromatographic separation
Espinoza, D., Tallvod, S., Andersson, N. & Nilsson, B., 2024 Apr 12, In: Journal of Chromatography A. 1720, 11 p., 464805.
Research output: Contribution to journal › Article › peer-review

Open Access
Tools for digital twins in continuous downstream processing
Tallvod, S., 2023 Nov 24, Lund: Department of Chemical Engineering, Lund University. 130 p.
Research output: Thesis › Doctoral Thesis (compilation)

Open Access
File

Cite this

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title = "Automation of Modeling and Calibration of Integrated Preparative Protein Chromatography Systems",

abstract = "With the increasing global demand for precise and efficient pharmaceuticals and the biopharma industry moving towards Industry 4.0, the need for advanced process integration, automation, and modeling has increased as well. In this work, a method for automatic modeling and calibration of an integrated preparative chromatographic system for pharmaceutical development and production is presented. Based on a user-defined system description, a system model was automatically generated and then calibrated using a sequence of experiments. The system description and model was implemented in the Python-based preparative chromatography control software Orbit.",

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KW - digital twin

KW - integrated continuous processes

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KW - preparative chromatography

KW - process automation

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ER -

Automation of Modeling and Calibration of Integrated Preparative Protein Chromatography Systems

Abstract

Subject classification (UKÄ)

Free keywords

Access to Document

Fingerprint

Research output

Automatic procedure for modelling, calibration, and optimization of a three-component chromatographic separation

Tools for digital twins in continuous downstream processing

Cite this