Autonomic nervous symptoms in primary Sjogren's; syndrome.

Thomas Mandl, Viktoria Granberg, Jan Apelqvist, Per Wollmer, Rolf Manthorpe, Lennart Jacobsson

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40 Citations (SciVal)


Objectives. Objective signs of autonomic dysfunction (AD) have been reported in patients with primary SS (pSS) while the presence of associated symptoms has not been systematically studied. Therefore, the aims of this study were (i) to assess the presence and severity of various AD symptoms in pSS patients and (ii) to relate AD symptoms to other clinical features of pSS. Methods. Thirty-eight pSS patients and 200 population-based controls were studied for presence and severity of AD symptoms using the Autonomic Symptom Profile (ASP), a validated self-completed questionnaire evaluating various AD symptoms. In addition, patients were investigated by three different objective autonomic nervous function tests. Results. pSS patients scored significantly higher in the parasympathetic [secretomotor disorder, urinary disorder, gastroparesis (females only) and pupillomotor disorder] as well as sympathetic (orthostatic intolerance and vasomotor disorder) ASP domains compared with controls. Consequently, the standardized ASP total score was significantly increased in pSS patients [1.77 (0.57, 3.15) vs - 0.21 (-0.82, 0.72); P = 0.00] and 45% of pSS patients had an ASP total score >/=2 s.d. Furthermore, the autonomic nervous function tests showed signs of objective parasympathetic and sympathetic dysfunction as well. However, the ASP domain and total scores showed limited associations with the objective autonomic nervous function test parameters as well as clinical and serological factors of pSS. Conclusions. pSS patients showed subjective and objective signs of both a parasympathetic and a sympathetic dysfunction. However, AD symptoms showed limited associations with objective autonomic nervous function as well as other clinical features of the disease.
Original languageEnglish
Pages (from-to)914-919
Issue number6
Publication statusPublished - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Diabetes Epidemiology and Neuropathy (013241560), Clinical Physiology and Nuclear Medicine Unit (013242320), Diabetes and Endocrinology (013241530), Department of Rheumatology (013036000)

Subject classification (UKÄ)

  • Rheumatology and Autoimmunity


  • Physiology
  • Cardiovascular
  • syndrome
  • Nervous
  • Primary Sjögren's
  • Autonomic symptoms


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