Research output per year
Research output per year
Daniel Willén, Roberto Mastio, Zackarias Söderlund, Sophie Manner, Gunilla Westergren-Thorsson, Emil Tykesson, Ulf Ellervik
Research output: Contribution to journal › Article › peer-review
We present a xylosylated naphthoxyloside carrying a terminal azide functionality that can be used for conjugation using click chemistry. We show that this naphthoxyloside serves as a substrate for β4GalT7 and induces the formation of soluble glycosaminoglycan (GAG) chains with physiologically relevant lengths and sulfation patterns. Finally, we demonstrate its usefulness by conjugation to the Alexa Fluor 647 and TAMRA fluorophores and coupling to a surface plasmon resonance chip for interaction studies with the hepatocyte growth factor known to interact with the GAG heparan sulfate.
Original language | English |
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Pages (from-to) | 2507-2515 |
Journal | Bioconjugate Chemistry |
Volume | 32 |
Issue number | 12 |
Early online date | 2021 |
DOIs | |
Publication status | Published - 2021 |
Research output: Thesis › Doctoral Thesis (compilation)
Research output: Thesis › Doctoral Thesis (compilation)
Ellervik, U. (Researcher), Tykesson, E. (Researcher), Malmström, A. (Researcher) & Mastio, R. (Research student)
2014/01/01 → …
Project: Research