B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

Adi Biram; Eitan Winter; Alice E. Denton; Irina Zaretsky; Bareket Dassa; Mats Bemark; Michelle A. Linterman; Gur Yaari; Ziv Shulman

doi:10.1016/j.celrep.2020.01.032

B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

Adi Biram, Eitan Winter, Alice E. Denton, Irina Zaretsky, Bareket Dassa, Mats Bemark, Michelle A. Linterman, Gur Yaari, Ziv Shulman

University of Gothenburg

Research output: Contribution to journal › Article › peer-review

Abstract

SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.

Original language	English
Pages (from-to)	1910-1922.e5
Journal	Cell Reports
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2020.01.032
Publication status	Published - 2020 Feb 11
Externally published	Yes

Free keywords

antibody
B cells
clonal diversification
germinal center
IgA
Peyer's patches
plasma cells
SAP
T follicular helper cells

Access to Document

10.1016/j.celrep.2020.01.032Licence: CC BY

Cite this

@article{e2c9799bfcb4425bbe75bc17ba8a7303,

title = "B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches",

abstract = "SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.",

keywords = "antibody, B cells, clonal diversification, germinal center, IgA, Peyer's patches, plasma cells, SAP, T follicular helper cells",

author = "Adi Biram and Eitan Winter and Denton, {Alice E.} and Irina Zaretsky and Bareket Dassa and Mats Bemark and Linterman, {Michelle A.} and Gur Yaari and Ziv Shulman",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = feb,

day = "11",

doi = "10.1016/j.celrep.2020.01.032",

language = "English",

volume = "30",

pages = "1910--1922.e5",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

AU - Biram, Adi

AU - Winter, Eitan

AU - Denton, Alice E.

AU - Zaretsky, Irina

AU - Dassa, Bareket

AU - Bemark, Mats

AU - Linterman, Michelle A.

AU - Yaari, Gur

AU - Shulman, Ziv

PY - 2020/2/11

Y1 - 2020/2/11

N2 - SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.

AB - SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.

KW - antibody

KW - B cells

KW - clonal diversification

KW - germinal center

KW - IgA

KW - Peyer's patches

KW - plasma cells

KW - SAP

KW - T follicular helper cells

U2 - 10.1016/j.celrep.2020.01.032

DO - 10.1016/j.celrep.2020.01.032

M3 - Article

C2 - 32049020

AN - SCOPUS:85079170606

SN - 2211-1247

VL - 30

SP - 1910-1922.e5

JO - Cell Reports

JF - Cell Reports

IS - 6

ER -

B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

Abstract

Free keywords

Access to Document

Fingerprint

Cite this