B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.

Ulrika Andreasson; Sara Ek; Hartmut Merz; Richard Rosenquist; Niels Andersen; Mats Jerkeman; Michael Dictor; Carl A K Borrebaeck

doi:10.1016/j.canlet.2007.10.031

B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.

Ulrika Andreasson, Sara Ek, Hartmut Merz, Richard Rosenquist, Niels Andersen, Mats Jerkeman, Michael Dictor, Carl A K Borrebaeck

Research output: Contribution to journal › Article › peer-review

Abstract

To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.

Original language	English
Pages (from-to)	138-145
Journal	Cancer Letters
Volume	259
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2007.10.031
Publication status	Published - 2008

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2007.10.031

http://www.ncbi.nlm.nih.gov/pubmed/18060687?dopt=Abstract

Cite this

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title = "B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.",

abstract = "To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.",

author = "Ulrika Andreasson and Sara Ek and Hartmut Merz and Richard Rosenquist and Niels Andersen and Mats Jerkeman and Michael Dictor and Borrebaeck, {Carl A K}",

year = "2008",

doi = "10.1016/j.canlet.2007.10.031",

language = "English",

volume = "259",

pages = "138--145",

journal = "Cancer Letters",

issn = "1872-7980",

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TY - JOUR

T1 - B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.

AU - Andreasson, Ulrika

AU - Ek, Sara

AU - Merz, Hartmut

AU - Rosenquist, Richard

AU - Andersen, Niels

AU - Jerkeman, Mats

AU - Dictor, Michael

AU - Borrebaeck, Carl A K

PY - 2008

Y1 - 2008

N2 - To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.

AB - To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.

U2 - 10.1016/j.canlet.2007.10.031

DO - 10.1016/j.canlet.2007.10.031

M3 - Article

C2 - 18060687

SN - 1872-7980

VL - 259

SP - 138

EP - 145

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.

Abstract

Subject classification (UKÄ)

UN SDGs

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